9087-70-1
9087-70-1 structure
- Name: Aprotinin acetate salt
- Chemical Name: Aprotinin
- CAS Number: 9087-70-1
- Molecular Formula: C284H432N84O79S7
- Molecular Weight: 6511.83000
- Catalog: Biochemical Enzymes and coenzymes
- Create Date: 2018-07-05 18:54:31
- Modify Date: 2026-06-30 18:44:10
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Aprotinin is a bovine pancreatic trypsin inhibitor (BPTI) inhibitor which inhibits trypsin and chymotrypsin with Kis of 0.06 pM and 9 nM, respectively.
| Name | Aprotinin |
|---|---|
| Synonyms |
basiancreatictrypsininhibitor
pancreatictrypsininhibitor Aprotinin, Bovine, Recombinant, Nicotiana sp., Animal-Free - - Calbiochem pancreaticbasictrypsininhibitor APROTININ, BOVINE LUNG FOR GELFILTRATION CHROMATOG kirrichter Aids043659 RecoMbinant aprotinin trypsininhibitor,pancreaticbasic Aprotinin from bovine lung, >=5400 KIU/mg EZNA KIT ENDO-FREE PLASMID GIGA kallikrein-trypsininactivator pancreatictrypsininhibitor(kunitz) Aprotinin from bovine lung, ca. 140 U/mg H-G-PRO-ASP-PHE-CYS-LEU-GLU-PRO-PRO-TYR-THR-GLY-PRO-CYS-LYS-ALA-G-ILE-ILE-G-TYR-PHE-TYR-ASN-ALA-LYS-ALA-GLY-LEU-CYS-GLN-THR-PHE-VAL-TYR-GLY-GLY-CYS-G-ALA-LYS-G-ASN-ASN-PHE-LYS-SER-ALA-GLU-ASP-CYS-MET-G-THR-CYS-GLY-GLY-ALA-OH Aprotinin froM bovine lung, ca. 140 U/Mg lyophil APROTININ FROM BOVINE LUNG CELL CULTURE TESTED APROTININ FROM BOVINE LUNG, LYOPH.,~7000 U/MG antilysine APROTININ-AGOSE Antilysi aprotininfrombovinelung Trypsin Inhibitor TRASYLOL EC: 3.4.21.9 bayera-128 antikrein TRYPSIN INHIBITOR, PANCREAS TYPE TRYPSIN INHIBITOR, BOVINE LUNG Monoclonal Anti-Acetylated Lysine antibody produced in mouse APROTININ, BOVINE APROTININ BOVINE LUNG rp-9921 riker Anti-Acetylated Lysine-Biotin antibody produced in rabbit APROTININ trazinin APROTININ, BOVINE AGOSE CONJUGATE Anti-Acetylated Lysine:HRP rulson onquinin Anti-Acetylated Lysine: Biotin Bovine pancreatic trypsin inhibitor antilysin APROTININ FROM BOVINE LUNG, ~8000 U/MG P ROTEIN TRYPSIN INHIBITOR (BASIC) APROTININ-AGOSE FROM BOVINE LUNG MFCD00130541 APROTININ FROM BOVINE LUNGAFFINITY PURIF IED Anti-Acetylated Lysine antibody produced in rabbit cas9004-04-0 Anti-Acetylated Lysine-Peroxidase antibody produced in rabbit Trypsin Inhibitor, pankreatisch basisch Aids-043659 Kunitz protease inhibitor trypsin-kallikreininhibitor(kunitz) APROTININ, BOVINE, RECOMBINANT fosten zymofren Aprotinin solution |
| Description | Aprotinin is a bovine pancreatic trypsin inhibitor (BPTI) inhibitor which inhibits trypsin and chymotrypsin with Kis of 0.06 pM and 9 nM, respectively. |
|---|---|
| Related Catalog | |
| Target |
Ki: 0.06 pM (Trypsin), 9 nM (Chymotrypsin)[1] |
| In Vitro | Aprotinin, a serine protease inhibitor isolated from bovine lung, is a complex protease inhibitor that is an antifibrinolytic, inhibits contact activation, and decreases the inflammatory response to cardiopulmonary bypass[2]. Aprotinin inhibits trypsin (bovine, Ki= 0.06 pM), chymotrypsin (bovine, Ki= 9 nM), plasmin (human, 0.23 nM)[1]. Aprotinin is also a competitive protein inhibitor of NOS activity. It inhibits NOS-I and NOS-II with Ki values of 50 μM and 78 μM, respectively[3]. Aprotinin significantly inhibits fibrinolysis with an IC50 of 0.16±0.05 μM[4]. |
| In Vivo | High dose aprotinin can reduce blood loss and transfusion requirements associated with primary cardiac procedures such as coronary artery bypass graft (CABG) or heart valve replacement surgery[5]. Aprotinin inhibits thrombus formation in a dose-dependent manner. Aprotinin at a dose of 1.5 mg kg-1 (bolus) and 3 mg kg-1 h-1 infusion (maintenance infusion) causes a tendency towards a reduction in bleeding time. Aprotinin significantly reduces the bleeding time starting at a dose of 3 mg kg-1 bolus plus 6 mg kg-1 h-1 showing a reduction of approximately 84%±2.9%. At the highest dose of 5 mg kg-1 and 10 mg kg-1 h-1, the strongest effects are observed[4]. Aprotinin may affect tumor necrosis factor-alpha (TNF) levels. Soluble TNFRI levels are significantly increased following I/R in the aprotinin treated wild type mice and not detected in all TNFRInull mice[6]. |
| Animal Admin | Rats: Male Wistar rats (180-220 g) are used in the study. Aprotinin is dissolved in physiological saline. Aprotinin is administered by bolus injection followed by a maintenance infusion. The doses given are 1.5 mg kg-1 and 3 mg kg-1 h-1, 3mg kg-1 and 6 mg kg-1 h-1 up to 5 mg kg-1 and 10 mg kg-1 h-1. Plasma concentrations for the two agents are assessed by pharmacokinetic studies in rats[4]. Mice: An intact mouse model of ischemia/reperfusion (30 min-I/60 min-R) is used and left ventricular peak + dP/dt is measured in wild type mice (WT, C57BL/6; n=10), WT mice with aprotinin (4mL/kg; n=10), transgenic mice devoid of the TNFRI (TNFRInull; n=10), and TNFRInull with aprotinin (n=10)[6]. |
| References |
| Molecular Formula | C284H432N84O79S7 |
|---|---|
| Molecular Weight | 6511.83000 |
| Exact Mass | 6507.00000 |
| Appearance | lyophilized powder | white |
| Storage condition | 2-8°C |
| Stability | Stable. Incompatible with strong oxidizing agents. |
| Water Solubility | glycerol: soluble3mg/mL, clear, colorless (equilibration buffer containing 5% glycerol) | Freely soluble in water and in aqueous buffers of low ionic strength. |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Hazard Codes | Xn,Xi |
| Risk Phrases | 42/43-36/37/38-20/21/22 |
| Safety Phrases | 22-45-36/37-36-26 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 1 |
| RTECS | YN5080000 |
| HS Code | 35040000 |