52571-45-6

52571-45-6 structure

Name: N4-Bz-2'-OMe-rC
Chemical Name: N4-Benzoyl-2'-O-methylcytidine
CAS Number: 52571-45-6
Molecular Formula: C₁₇H₁₉N₃O₆
Molecular Weight: 361.35
Catalog: Biochemical Nucleoside drugs Nucleoside intermediate
Create Date: 2018-04-27 08:00:00
Modify Date: 2024-01-10 19:45:44
N4-Benzoyl-2’-O-methylcytidine is a cytidine analog. Cytidine analogs have a mechanism of inhibiting DNA methyltransferases (such as Zebularine, HY-13420), and have potential anti-metabolic and anti-tumor activities[1].

Name	N4-Benzoyl-2'-O-methylcytidine
Synonyms	N-[1-[(2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxyoxolan-2-yl]-2-oxopyrimidin-4-yl]benzamide N4-Bz-2'-OMe-rC

Description	N4-Benzoyl-2’-O-methylcytidine is a cytidine analog. Cytidine analogs have a mechanism of inhibiting DNA methyltransferases (such as Zebularine, HY-13420), and have potential anti-metabolic and anti-tumor activities[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog
References	[1]. Gowher H, et al. Mechanism of inhibition of DNA methyltransferases by cytidine analogs in cancer therapy. Cancer Biol Ther. 2004 Nov;3(11):1062-8.

Density	1.49g/cm3
Melting Point	174-175ºC
Molecular Formula	C₁₇H₁₉N₃O₆
Molecular Weight	361.35
Exact Mass	361.12700
PSA	122.91000
Appearance	Powder \| White to Pale Yellow
Index of Refraction	1.659

Hazard Codes	Xi

73793-16-5

~79%

52571-45-6

Literature: Chavis, C.; Dumont, F.; Wightman, R. H.; Ziegler, J. C.; Imbach, J. L. Journal of Organic Chemistry, 1982 , vol. 47, # 2 p. 202 - 206

69304-43-4

74-88-4

~56%

52571-45-6

Literature: Gladkaya, V. A.; Levitskaya, Z. V.; Shalamai, A. S.; Usenko, L. S.; Dashevskaya, T. A. Chemistry of Natural Compounds, 1989 , vol. 25, # 4 p. 488 - 492

2140-72-9

52571-45-6

Literature: Isis Pharmceuticals, Inc. Patent: US5646265 A1, 1997 ; Title/Abstract Full Text Show Details ISIS Pharmaceuticals, Inc. Patent: US5914396 A1, 1999 ;

68045-07-8

52571-45-6

Literature: Chavis, C.; Dumont, F.; Wightman, R. H.; Ziegler, J. C.; Imbach, J. L. Journal of Organic Chemistry, 1982 , vol. 47, # 2 p. 202 - 206

26661-13-2

52571-45-6

Literature: Chavis, C.; Dumont, F.; Wightman, R. H.; Ziegler, J. C.; Imbach, J. L. Journal of Organic Chemistry, 1982 , vol. 47, # 2 p. 202 - 206

22224-41-5

52571-45-6

Literature: Chavis, C.; Dumont, F.; Wightman, R. H.; Ziegler, J. C.; Imbach, J. L. Journal of Organic Chemistry, 1982 , vol. 47, # 2 p. 202 - 206

13089-48-0

52571-45-6

Literature: Gladkaya, V. A.; Levitskaya, Z. V.; Shalamai, A. S.; Usenko, L. S.; Dashevskaya, T. A. Chemistry of Natural Compounds, 1989 , vol. 25, # 4 p. 488 - 492

93-97-0

2140-72-9

52571-45-6

Literature: Metelev, Valerii G.; Krynetskaya, Natalya F.; Purmal, Andrei A.; Shabarova, Zoya A.; Tocik, Zdenek; et al. Collection of Czechoslovak Chemical Communications, 1990 , vol. 55, # 11 p. 2781 - 2786

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