117977-21-6

117977-21-6 structure

Name: Rabeprazole thioether
Chemical Name: Rabeprazole Sulfide
CAS Number: 117977-21-6
Molecular Formula: C₁₈H₂₁N₃O₂S
Molecular Weight: 343.443
Catalog: Pharmaceutical intermediate Heterocyclic compound Pyridine compound Methylpyridine
Create Date: 2018-02-20 08:00:00
Modify Date: 2026-07-07 20:00:39
Rabeprazole Sulfide is an active metabolite of Rabeprazole. Rabeprazole is a proton pump inhibitor that suppresses gastric acid secretion through an interaction with (H+/K+)-ATPase in gastric parietal cells. Rabeprazole markedly inhibits the motility of H. pylori. Rabeprazole has the potential for various peptic diseases treatment[1][2].

Name	Rabeprazole Sulfide
Synonyms	abrazole Sulfide MFCD08063845 Rabrazole Related Compound E.doc 2-[[[4-(3-METHOXYPROPOXY)3-METHYL-2-PYRIDINYL] METHYL]THIO]1HBENZIMIDAZOLE 2-[[[4-(3-Methoxypropoxy)-3-Methylpyridinyl] Methyl]Thio]- 1H-Benzimidazole (Sulp) Rabrazole sulphideQ: What is Rabrazole sulphide Q: What is the CAS Number of Rabrazole sulphide Q: What is the storage condition of Rabrazole sulphide 2-[[4-(3-Methoxypropoxy)-3-methyl-pyridin-2-yl]methylthio]benzoimidazole Rabrazole Related CoMpound E 2-({[4-(3-Methoxypropoxy)-3-methyl-2-pyridinyl]methyl}sulfanyl)-1H-benzimidazole 2-[{4-(3-MethoxyPropoxy)-3-MethylPyridine-2-Yi}-Methylthio]-1H-Benzimidazole Rabrazole RC E 2-[[[4-(3-Methoxypropoxy)-3-methylpyridinyl] methyl]thio]- 1H-benzimidazole (RabeSulphide) 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl) 2-(chloromethyl)-4-(3-methoxypropoxy)-3-methylpyridine hydro 2-[[4-(3-Methoxypropoxy)-3-methyl-2-pyridyl]methylthio]benzimidazole 2-({[4-(3-Methoxypropoxy)-3-Methylpyridin-2-yl]Methyl}sulfanyl)-1H-1,3-benzodiazole Rabrazole Sulfide / Rabrazole Related Compound-E 2-[[(3-METHYL-4-(3-METHOXYPROPOXY)PYRIDINYL)METHYL]THIO]-1H-BENZIMIDAZOLE Rabrazole Sulfide 2-{[4-(3-Methoxypropoxy)-3-Methylpyridine-2-Yl]-Methythio}-1 Rabrazole Impurity 3（Rabrazole Impurity B） 2-[(4-METHOXYPROPOXY-3-METHYL-2-PYRIDINYL)-METHYLTHIO]-BENZIMIDAZOLE Rabrazole Sodium Impurity Ⅲ:2-{[4-(3-Methoxypropoxy)-3-methylpyridine-2-yl]methylthio}-1H-benzimidazole 2-(((4-(3-Methoxypropoxy)-3-Methylpyridin-2-yl)Methyl)thio)-1H-benzo[d]iMidazole 2-[[4-(3-METHOXYPROPOXY)-3-METHYLPYRIDIN-2-YL]METHYLTHIO}-1H-BENZIMIDAZOLE Rabrazole Related Compound E (25 mg) (2-{[4-(3-Methoxypropoxy)-3-methyl-2-pyridyl]methylthio}benzimidazole) rabrazole sulphide 2-{[4-(3-methoxypropoxy)-3-met 1H-Benzimidazole, 2-[[[4-(3-methoxypropoxy)-3-methyl-2-pyridinyl]methyl]thio] 2-{[4-(3-Methoxypropoxy)-3-methylpyridine-2-yl]methylthio}-1H-benzimidazole ISO 9001：2015 REACH 2-[[(4-(3-Methoxypropoxy)- 3-methyl-2-pyridinyl)-2-methyl]thio]- 1H-benzimidazole (+)-Limacine Rabrazole Related Compound E (2-{[4-(3-Methoxypropoxy)-3-methyl-2-pyridyl]methylthio}benzimidazole) Rabrazole Impurity B/ Rabrazole Related Compound E (Rabrazole Sulfide) Rabrazole-3 2-[[4-(3-Methoxypropoxy)-3-Methylpyridin-2-yl]Methylsulfanyl]-1h-benziMidazole 2-[[[4-(3-Methoxypropoxy)-3-methylpiridine-2-yl]methyl]thio]-1H-benzimidazole 2-{[4-(3-Methoxypropoxy)-3-Methylpyridine-2-yl]Met Rabrazole Impurity 7 2-(((4-(3-methoxypropoxy)-3-methylpyridine-2-yl) methyl) thio)-1H-benzo[d]imidazole 2-([4-(3-METHOXYPROPOXY)-3-METHYLPYRIDINE-2-YL]-METHYTHIO)1H-BENZIMIDAZOLE 2-(((4-(3-METHOXYPROPOXY)-3-METHYL-2-PYRIDINYL)METHYL)THIO)-1H-BENZIMIDAZOLE Rabrazole Related Compound E (2-{[4-(3-Methoxypropoxy)-3-methyl-2-pyridyl]methylthio}benzimidazol 2-[[4-(3-methoxypropoxy)-3-methylpyridin-2-yl]methylsulfanyl]-1H-benzimidazole (+)-Fanhinoline 2-[[[3-Methyl-4-(3-methoxypropoxy)-2-pyridyl]methyl]thio]-1H-benzimidazole Rabrazole Sulfide (Rabrazole Impurity) 2-[[[4-(3-Methoxypropoxy)-3-methyl Rabrazole Impurity B 2-({[4-(3-Methoxypropoxy)-3-methylpyridin-2-yl]methyl}sulfanyl)-1H-benzimidazole 2-[[[4-(3-Methoxy Propoxy)-3-methyl pyridine-2-yl ]methyl ] thio]-1H-benzimidazole Rabrazole Thioether 2-[[[4-(3-Methoxy Propoxy-3-mthyl-2Pyridyl] Methyl]Thio]-1H-Benzimidazole 2-[[[4-(3-METHOXY PROPOXY)-3-METHYL PYRIDINE-2-YL]METHYL] THIO]-1H-BENZIMIDAZOLE 2-{[4-(3-Methoxypropoxy)-3-methylpyridine-2-yl]methylthio}-1H-benzimidazole/Rabrazole sulfide Ribrazole condensate Rabrazole Sulfide > Rabrazole Sulfide IMpurity 2-[[4-(3-Methoxypropoxy)-3-Methyl-2-pyridyl]Methylthio]benziMidazole /43 Rebrazole thioether 2-{[4-(3-Methoxypropoxy)-3-methylpyridine-2- yl]methylthio}-1H-benzimidazole (Rabe Sulphide) 2-[[[4-(3-Methoxypropoxy)-3-methylpyridine-2-yl ]methyl]thio]-1H-benzimidazole 2-[[[4-(3-Methoxy Propoxy)-3-methyl pyridine-2-yl]methyl ] thio]-1H-benzimidazole Rabrazole IMpurity F Rabrazole Impurity B (Rabrazole Sulfide)

Description	Rabeprazole Sulfide is an active metabolite of Rabeprazole. Rabeprazole is a proton pump inhibitor that suppresses gastric acid secretion through an interaction with (H+/K+)-ATPase in gastric parietal cells. Rabeprazole markedly inhibits the motility of H. pylori. Rabeprazole has the potential for various peptic diseases treatment[1][2].
Related Catalog	Research Areas >> Infection Research Areas >> Inflammation/Immunology Signaling Pathways >> Membrane Transporter/Ion Channel >> Proton Pump Signaling Pathways >> Anti-infection >> Bacterial
References	[1]. Uno T, et al. Determination of rabeprazole and its active metabolite, rabeprazole thioether in human plasma by column-switching high-performance liquid chromatography and its application to pharmacokinetic study. J Chromatogr B Analyt Technol Biomed Life Sci. 2005 Sep 25;824(1-2):238-43. [2]. Tsutsui N, et al. A novel action of the proton pump inhibitor rabeprazole and its thioether derivative against the motility of Helicobacter pylori. Antimicrob Agents Chemother. 2000 Nov;44(11):3069-73.

Density	1.3±0.1 g/cm3
Boiling Point	546.4±60.0 °C at 760 mmHg
Melting Point	120.5-121.5ºC
Molecular Formula	C₁₈H₂₁N₃O₂S
Molecular Weight	343.443
Flash Point	284.2±32.9 °C
Exact Mass	343.135437
PSA	85.33000
LogP	3.53
Vapour Pressure	0.0±1.5 mmHg at 25°C
Index of Refraction	1.636
Storage condition	-20°C Freezer

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P305 + P351 + P338
Hazard Codes	Xi
RIDADR	NONH for all modes of transport
HS Code	2933990090

117977-20-5

134469-07-1

~99%

117977-21-6

Literature: EP1775292 A1, ; Page/Page column 13; 14 ;

103312-62-5

1589-49-7

~29%

117977-21-6

Literature: Journal of Heterocyclic Chemistry, , vol. 43, # 6 p. 1447 - 1453

37699-43-7

117977-21-6

Literature: Journal of Heterocyclic Chemistry, , vol. 43, # 6 p. 1447 - 1453

59886-90-7

117977-21-6

Literature: Journal of Heterocyclic Chemistry, , vol. 43, # 6 p. 1447 - 1453

134469-07-1

117977-21-6

Literature: Journal of Heterocyclic Chemistry, , vol. 43, # 6 p. 1447 - 1453

Precursor 6
117977-20-5 134469-07-1 103312-62-5 1589-49-7
37699-43-7 59886-90-7
DownStream 3
117976-90-6 117976-89-3 117976-47-3

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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