389614-94-2

389614-94-2 structure

Name: EA4
Chemical Name: 7-chloro-6-[4-(diethylamino)phenyl]quinoline-5,8-dione
CAS Number: 389614-94-2
Molecular Formula: C₁₉H₁₇ClN₂O₂
Molecular Weight: 340.803
Catalog: Signaling Pathways Metabolic Enzyme/Protease Phospholipase
Create Date: 2016-11-05 08:28:00
Modify Date: 2025-08-25 14:54:23
EA4, a derivative of quinone, is an inhibitor for both rPLA and cPLA. EA4 can inhibit rPLA2 with a Ki value of 130 μM. EA4 can be used for the research of hemostasis, thrombosis, and erythropoiesis[1].

Name	7-chloro-6-[4-(diethylamino)phenyl]quinoline-5,8-dione
Synonyms	7-Chloro-6-[4-(diethylamino)phenyl]-5,8-quinolinedione 5,8-Quinolinedione, 7-chloro-6-[4-(diethylamino)phenyl]- ea4

Description	EA4, a derivative of quinone, is an inhibitor for both rPLA and cPLA. EA4 can inhibit rPLA2 with a Ki value of 130 μM. EA4 can be used for the research of hemostasis, thrombosis, and erythropoiesis[1].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Metabolic Enzyme/Protease >> Phospholipase
Target	Ki: 130 μM (rPLA2)[1]
In Vitro	EA4（9 μM，24 μM）抑制 rPLA2 和 cPLA2[1]。 EA4 可抑制 rPLA2，Ki 值为 130 μM[1]。 EA4 (50 μM) 以时间依赖性方式显著抑制 A23187 诱导的人和牛红细胞释放 AA[1]。
References	[1]. Shin, Hae Sook et al. Purification and characterization of a cytosolic, 42-kDa and Ca2+-dependent phospholipase A2 from bovine red blood cells: its involvement in Ca2+-dependent release of arachidonic acid from mammalian red blood cells. The Journal of biological chemistry vol. 277,23 (2002): 21086-94.