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  • DC Chemicals Limited
  • China
  • Product Name: NCX4040
  • Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
  • Purity: 98.0%
  • Stocking Period: 3 Day
  • Contact: Tony Cao

287118-97-2

287118-97-2 structure
287118-97-2 structure
  • Name: 2-(ACETYLOXY)-4-[(NITROOXY)METHYL]PHENYL ESTER, BENZOIC ACID
  • Chemical Name: 2-(Acetyloxy)benzoic acid 4-(nitroxymethyl)phenyl ester
  • CAS Number: 287118-97-2
  • Molecular Formula: C16H13NO7
  • Molecular Weight: 331.27700
  • Create Date: 2018-12-30 07:02:26
  • Modify Date: 2024-04-04 23:07:05
  • NCX4040 (NO-Aspirin), a non-steroidal anti-inflammatory drug (NSAID), is a nitric oxide (NO) releasing form of Aspirin. NCX4040 induces apoptosis in PC3 metastatic prostate cancer cells. NCX4040 has anti-inflammatory and anti-cancer effects[1].

Name 2-(Acetyloxy)benzoic acid 4-(nitroxymethyl)phenyl ester
Synonyms [4-(nitrooxymethyl)phenyl] 2-acetyloxybenzoate
Description NCX4040 (NO-Aspirin), a non-steroidal anti-inflammatory drug (NSAID), is a nitric oxide (NO) releasing form of Aspirin. NCX4040 induces apoptosis in PC3 metastatic prostate cancer cells. NCX4040 has anti-inflammatory and anti-cancer effects[1].
Related Catalog
In Vitro NCX4040 significantly induces hydrogen peroxide formation with ensuing oxidative stress and mitochondrial depolarization resulting in lipid peroxidation, cell cycle arrest, inhibition of colony growth and induction of apoptosis in PC3 cells[1]. NCX4040 (10-50 μM) inhibits migration potential of PC3 cells by depolymerizing F-actin and promoting anoikis[1]. NCX4040 down regulates cyclin D1 expression in PC3 cells. Western blot analysis revealed that significant down regulation of key anti-apoptotic markers such as cellular inhibitor of apoptosis protein-1 (cIAP1), X-linked inhibitor of apoptosis (XIAP), survivin, and Cellular-Myc (c-Myc)[1]. NCX4040-treated cells showes upregulation of phosho histone H2AX (pH2AX), cleaved caspase3 and cleaved Poly [ADP-ribose] polymerase 1 (PARP1)[1].
References

[1]. Somaiah Chinnapaka, et al. Nitro aspirin (NCX4040) induces apoptosis in PC3 metastatic prostate cancer cells via hydrogen peroxide (H 2 O 2)-mediated oxidative stress. Free Radic Biol Med. 2019 Nov 1;143:494-509.

Molecular Formula C16H13NO7
Molecular Weight 331.27700
Exact Mass 331.06900
PSA 107.65000
LogP 3.06260
Storage condition 20°C
Symbol GHS05 GHS07 GHS09
GHS05, GHS07, GHS09
Signal Word Danger
Hazard Statements H317-H318-H400
Precautionary Statements P273-P280-P305 + P351 + P338
Hazard Codes C
Risk Phrases 41-43
Safety Phrases 26-36/37-39
RIDADR UN 3077 9 / PGIII