Name | radicicol |
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Synonyms |
monorden
monorderne [Biotinyl]-Radicicol (1aR,2Z,4E,14R,15aR)-8-Chloro-9,11-dihydroxy-14-methyl-1a,14,15,15a-tetrahydro-6H-oxireno[e][2]benzoxacyclotetradecine-6,12(7H)-dione Monorden/Radicicol humicola fuscoatra Radicicol from Diheterospora chlamydosporia 6H-Oxireno[e][2]benzoxacyclotetradecin-6,12(7H)-dione, 8-chloro-1a,14,15,15a-tetrahydro-9,11-dihydroxy-14-methyl-, (1aR,2Z,4E,14R,15aR)- MFCD01709459 KF9-A RADISICOL Radicicol [TAMRA]-Radicicol MONORODENE FO-4910 |
Description | Radicicol is an inhibitor of the ATPase/kinase with IC50 values of 1 μM, 100 μM and 400 μM, respectively for Hsp90, Topo VI and PDK3 [1]. Radicicol inhibits a wide variety of tumor cell lines by targeting Hsp90, binds to the ATPase domain of Hsp90 and prevents maturation of Hsp90 clients, leading to proteasomal degradation [2]. Radicicol is an antifungal antibiotic with antimalarial activity, impairs mitochondrial replication by targeting P. falciparum topoisomerase VIB[2]. Radicicol is an inhibitor of fat mass and obesity-associated protein (FTO), exhibits a dose-dependent inhibition of FTO demethylation activity with an IC50 value of 16.04 µM[3]. |
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Related Catalog | |
Target |
IC50: of 1 μM (Hsp90), 100 μM (Topo VI) and 400 μM (PDK3)[1] |
References |
Density | 1.4±0.1 g/cm3 |
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Boiling Point | 656.2±55.0 °C at 760 mmHg |
Melting Point | 190-194ºC |
Molecular Formula | C18H17ClO6 |
Molecular Weight | 364.777 |
Flash Point | 350.7±31.5 °C |
Exact Mass | 364.071381 |
PSA | 96.36000 |
LogP | 1.53 |
Vapour Pressure | 0.0±2.0 mmHg at 25°C |
Index of Refraction | 1.583 |
Storage condition | -20°C |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
|
Symbol |
GHS06, GHS08 |
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Signal Word | Danger |
Hazard Statements | H301-H340-H350 |
Precautionary Statements | Missing Phrase - N15.00950417-P201-P280-P308 + P313 |
Hazard Codes | Xn: Harmful; |
Risk Phrases | R22 |
Safety Phrases | 26 |
RIDADR | UN 2811 6.1/PG 3 |
WGK Germany | 1 |
RTECS | RR1105000 |
Hazard Class | 6.1 |
HS Code | 29322090 |
Precursor 8 | |
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DownStream 0 |