23964-58-1

23964-58-1 structure

Name: Articaine
Chemical Name: methyl 4-methyl-3-[2-(propylamino)propanoylamino]thiophene-2-carboxylate
CAS Number: 23964-58-1
Molecular Formula: C₁₃H₂₀N₂O₃S
Molecular Weight: 284.37500
Catalog: Signaling Pathways Immunology/Inflammation NOD-like Receptor (NLR)
Create Date: 2018-09-12 01:05:36
Modify Date: 2025-08-25 08:08:38
Articaine (Hoe-045 free base) is an amide anaesthetic containing an ester group, reversibly binding to the α-subunit of the voltage-gated sodium channels within the inner cavity of the nerve, can provide effective pain relief. Articaine ameliorates LPS-induced acute kidney injury via inhibition of NF-ĸB activation and the NLRP3 inflammasome pathway[1][2][3].

Name	methyl 4-methyl-3-[2-(propylamino)propanoylamino]thiophene-2-carboxylate
Synonyms	4-Methyl-3-(2-(propylamino)propionamido)-2-thiophenecarboxylic acid,methyl ester Carticaine Articainum [INN-Latin] Methyl (4-methyl-3-(2-(propylamino)propionamido)-2-thiophencarboxylat) Articaina [INN-Spanish] 3-(N-propyl-2-amino-propionylamino)-2-carbomethoxy-4-methylthiophene Articaine Articainum Hoe-045 MFCD00190157 Articaina

Description	Articaine (Hoe-045 free base) is an amide anaesthetic containing an ester group, reversibly binding to the α-subunit of the voltage-gated sodium channels within the inner cavity of the nerve, can provide effective pain relief. Articaine ameliorates LPS-induced acute kidney injury via inhibition of NF-ĸB activation and the NLRP3 inflammasome pathway[1][2][3].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> Sodium Channel Signaling Pathways >> Immunology/Inflammation >> NOD-like Receptor (NLR) Research Areas >> Inflammation/Immunology
Target	NF-ĸB, NLRP3, sodium channel[2][3]
References	[1]. Yapp KE, et al. Articaine: a review of the literature. Br Dent J. 2011 Apr 9;210(7):323-9. [2]. Zhao G, et al. Local anesthetic articaine ameliorates LPS-induced acute kidney injury via inhibition of NF-ĸB activation and the NLRP3 inflammasome pathway. J Biochem Mol Toxicol. 2020 Oct;34(10):e22554. [3]. Snoeck M. Articaine: a review of its use for local and regional anesthesia. Local Reg Anesth. 2012;5:23-33.

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302
Precautionary Statements	P301 + P312 + P330
RIDADR	NONH for all modes of transport