CHEMICAL IDENTIFICATION
-
RTECS NUMBER :
-
GH0982000
-
CHEMICAL NAME :
-
Colchicoside
-
CAS REGISTRY NUMBER :
-
477-29-2
-
BEILSTEIN REFERENCE NO. :
-
0072204
-
LAST UPDATED :
-
199612
-
DATA ITEMS CITED :
-
5
-
MOLECULAR FORMULA :
-
C27-H33-N-O11
-
MOLECULAR WEIGHT :
-
547.61
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
-
TYPE OF TEST :
-
LDLo - Lowest published lethal dose
-
ROUTE OF EXPOSURE :
-
Intracerebral
-
SPECIES OBSERVED :
-
Rodent - rat
-
DOSE/DURATION :
-
75 ug/kg
-
TOXIC EFFECTS :
-
Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Behavioral - excitement
-
REFERENCE :
-
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 109,386,1957
-
TYPE OF TEST :
-
LDLo - Lowest published lethal dose
-
ROUTE OF EXPOSURE :
-
Parenteral
-
SPECIES OBSERVED :
-
Rodent - rat
-
DOSE/DURATION :
-
75 ug/kg
-
TOXIC EFFECTS :
-
Details of toxic effects not reported other than lethal dose value
-
REFERENCE :
-
FRPSAX Farmaco, Edizione Scientifica. (Casella Postale 227, 27100 Pavia, Italy) V.8-43 1953-88 For publisher information, see FRMCE8 Volume(issue)/page/year: 15,533,1960
-
TYPE OF TEST :
-
LD50 - Lethal dose, 50 percent kill
-
ROUTE OF EXPOSURE :
-
Oral
-
SPECIES OBSERVED :
-
Rodent - mouse
-
DOSE/DURATION :
-
84 mg/kg
-
TOXIC EFFECTS :
-
Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Behavioral - excitement
-
REFERENCE :
-
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 94,453,1953
-
TYPE OF TEST :
-
LD50 - Lethal dose, 50 percent kill
-
ROUTE OF EXPOSURE :
-
Intraperitoneal
-
SPECIES OBSERVED :
-
Rodent - mouse
-
DOSE/DURATION :
-
280 mg/kg
-
TOXIC EFFECTS :
-
Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Behavioral - excitement
-
REFERENCE :
-
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 109,386,1957
-
TYPE OF TEST :
-
LD50 - Lethal dose, 50 percent kill
-
ROUTE OF EXPOSURE :
-
Intravenous
-
SPECIES OBSERVED :
-
Rodent - mouse
-
DOSE/DURATION :
-
320 mg/kg
-
TOXIC EFFECTS :
-
Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Behavioral - excitement
-
REFERENCE :
-
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 94,453,1953
|
