7336-33-6

7336-33-6 structure

Name: Desmethylcolchicine
Chemical Name: N-[(7S)-3-hydroxy-1,2,10-trimethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide
CAS Number: 7336-33-6
Molecular Formula: C₂₀H₂₃NO₅
Molecular Weight: 357.40000
Catalog: Research Areas Inflammation/Immunology
Create Date: 2016-09-10 15:02:03
Modify Date: 2026-10-14 17:30:54
3-Demethylcolchicine, a colchicine metabolite, possesses a hydroxy-group on its carbon ring that could participate in radical scavenging and markedly inhibits the carrageenin edema[1][2].

Name	N-[(7S)-3-hydroxy-1,2,10-trimethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide
Synonyms	O3-Demethylcolchicine Colchicine 3-Demethyl Impurity Acetamide, N-[(7S)-5,6,7,9-tetrahydro-3-hydroxy-1,2,10-trimethoxy-9-oxobenzo[a]htalen-7-yl] 3-DesMethylcolchicine Colchiciine,3-desmethyl 3-O-Demethylcolchicine 3-Demethylcolchicine Colchicine,2-demethyl Colchicine Impurity E (S)-N-(3-hydroxy-1,2,10-trimethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]htalen-7-yl)acetamide N-[(7S,12a)-3-Hydroxy-1,2,10-trimethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]htalen-7-yl]acetamide (3 N-[(7S)-5,6,7,9-Tetrahydro-3-hydroxy-1,2,10-triMethoxy-9-oxobenzo[a]htalen-7-yl]-acetaMide Colchicine Impurity E (3-O-Demethyl Colchicine) N-[[(7S)-3-Hydroxy-1,2,10-trimethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]htalene]-7α-yl]acetamide 3-Desmethylcolchicine N-(3-hydroxy-1,2,10-trimethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]htalen-7-yl)acetamide N-[(7S,12a)-3-Hydroxy-1,2,10-trimethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]htalen-7-yl]acetamide (3-O-Demethylcolchicine) 3-demethylcolchicine, 10 mM in DMSO N-[(7S)-3-hydroxy-1,2,10-trimethoxy-9-oxo-6,7-dihydro-5H-benzo[a]htalen-7-yl]acetamide crageenin,3 demethylcolchicine,inhibit,Inhibitor,scavenging,colchicine,3-Demethylcolchicine,edema,Reactive Oxygen Species,metabolite,3demethylcolchicine,radical (S)-7-Acetylamino-6,7-dihydro-3-hydroxy-1,2,10-trimethoxybenzo[a]htalen-9(5H)-one Colchicine Impurity 5（Colchicine Impurity E） (-)-3-Demethylcolchicine

Description	3-Demethylcolchicine, a colchicine metabolite, possesses a hydroxy-group on its carbon ring that could participate in radical scavenging and markedly inhibits the carrageenin edema[1][2].
Related Catalog	Research Areas >> Inflammation/Immunology
References	[1]. Modriansky M, et al. Anti-/pro-oxidant effects of phenolic compounds in cells: are colchicine metabolites chain-breaking antioxidants?. Toxicology. 2002;177(1):105-117. [2]. Sugio K, et al. Separation of tubulin-binding and anti-inflammatory activity in colchicine analogs and congeners. Life Sci. 1987;40(1):35-39.

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 24,636,1981

Hazard Codes	Xi

477-29-2

~89%

7336-33-6

64-86-8

7336-33-6

Literature: Maier, Ulrich H.; Zenk, Meinhart H. Tetrahedron Letters, 1997 , vol. 38, # 42 p. 7357 - 7360