477-29-2

• 常用中文名：秋水仙碱苷
• 常用英文名：Colchicoside
• CAS号：477-29-2
• 分子式：C₂₇H₃₃NO₁₁
• 分子量：547.55
• 相关类别： 生物化工 中草药成分
• 发布时间：2018-03-30 08:00:00
• 更新时间：2024-01-02 19:41:39
• Colchicoside 是一种具有抗利什曼原虫和抗利什曼原虫活性的生物活性生物碱 (tropolone alkaloid) [1]。

名称

• 中文名: 秋水仙碱苷
• 英文名: Colchicoside
• 英文别名: Acetamide, N-[(7S)-3-(β-D-glucopyranosyloxy)-5,6,7,9-tetrahydro-1,2,10-trimethoxy-9-oxobenzo[a]heptalen-7-yl]-; N-[(7S)-3-(β-D-Glucopyranosyloxy)-1,2,10-trimethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl]acetamide; colchicoside

物化性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 929.0±65.0 °C at 760 mmHg
• 熔点: 194-197ºC
• 分子式: C₂₇H₃₃NO₁₁
• 分子量: 547.55
• 闪点: 515.6±34.3 °C
• 精确质量: 547.205383
• PSA: 173.24000
• LogP: -1.76
• 蒸汽压: 0.0±0.3 mmHg at 25°C
• 折射率: 1.636
• 储存条件: 库房低温,通风,干燥,与食品原料分开存放

生物活性

• 描述: Colchicoside 是一种具有抗利什曼原虫和抗利什曼原虫活性的生物活性生物碱 (tropolone alkaloid) [1]。
• 相关类别:
  研究领域 >> 感染
• 参考文献:

  [1]. Mohammad Azadbakht, et al. Tropolone alkaloids from Colchicum kurdicum (Bornm.) Stef. (Colchicaceae) as the potent novel antileishmanial compounds; purification, structure elucidation, antileishmanial activities and molecular docking studies. Exp Parasitol. 2020 Jun;213:107902.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : GH0982000 CHEMICAL NAME : Colchicoside CAS REGISTRY NUMBER : 477-29-2 BEILSTEIN REFERENCE NO. : 0072204 LAST UPDATED : 199612 DATA ITEMS CITED : 5 MOLECULAR FORMULA : C27-H33-N-O11 MOLECULAR WEIGHT : 547.61 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intracerebral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 75 ug/kg TOXIC EFFECTS : Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Behavioral - excitement REFERENCE : AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 109,386,1957 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Parenteral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 75 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : FRPSAX Farmaco, Edizione Scientifica. (Casella Postale 227, 27100 Pavia, Italy) V.8-43 1953-88 For publisher information, see FRMCE8 Volume(issue)/page/year: 15,533,1960 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 84 mg/kg TOXIC EFFECTS : Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Behavioral - excitement REFERENCE : AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 94,453,1953 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 280 mg/kg TOXIC EFFECTS : Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Behavioral - excitement REFERENCE : AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 109,386,1957 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 320 mg/kg TOXIC EFFECTS : Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Behavioral - excitement REFERENCE : AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 94,453,1953

安全

• 危害码 (欧洲): T+

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