93261-39-3

93261-39-3 structure

Name: JMC-4
Chemical Name: 1-Naphthyl 3,5-dinitrobenzoate
CAS Number: 93261-39-3
Molecular Formula: C₁₇H₁₀N₂O₆
Molecular Weight: 338.27
Catalog: Signaling Pathways Metabolic Enzyme/Protease 5-Lipoxygenase
Create Date: 2017-08-15 00:31:26
Modify Date: 2024-01-08 02:54:46
1-Naphthyl 3,5-dinitrobenzoate is a potent 5-lipoxygenase inhibitor with IC50 values of 1.04 µM and 3.6 µM for 5-LOX and mPGES-1, respectively. 1-Naphthyl 3,5-dinitrobenzoate has strong inhibition activity in the human whole blood (HWB) assay with an IC50 value of 8.6 μM. 1-Naphthyl 3,5-dinitrobenzoate can be used in research of inflammation[1].

Name	1-Naphthyl 3,5-dinitrobenzoate
Synonyms	3,5-Dinitro-benzoesaeure-tetrahydrofurfurylester 3,5-dinitro-benzoic acid-[1]naphthyl ester 2-(3,5-dinitro-benzoyloxymethyl)-tetrahydro-furan 3,5-dinitro-benzoic acid tetrahydrofurfuryl ester tetrahydro-furfuryl alcohol 3,5-Dinitro-benzoesaeure-[1]naphthylester 2-Furanmethanol,tetrahydro-,3,5-dinitrobenzoate 3,5-Dinitro-benzoesaeure-naphthyl-(1)-ester

Description	1-Naphthyl 3,5-dinitrobenzoate is a potent 5-lipoxygenase inhibitor with IC50 values of 1.04 µM and 3.6 µM for 5-LOX and mPGES-1, respectively. 1-Naphthyl 3,5-dinitrobenzoate has strong inhibition activity in the human whole blood (HWB) assay with an IC50 value of 8.6 μM. 1-Naphthyl 3,5-dinitrobenzoate can be used in research of inflammation[1].
Related Catalog	Research Areas >> Inflammation/Immunology Signaling Pathways >> Metabolic Enzyme/Protease >> 5-Lipoxygenase
References	[1]. Wu Y, et, al. Dynamic modeling of human 5-lipoxygenase-inhibitor interactions helps to discover novel inhibitors. J Med Chem. 2012 Mar 22;55(6):2597-605.

90-15-3

99-33-2

93261-39-3

Precursor 2
90-15-3 99-33-2
DownStream 0