Name | Timosaponin B II |
---|---|
Synonyms |
(3β,5β,25S)-26-(β-D-Glucopyranosyloxy)-22-hydroxyfurostan-3-yl 2-O-β-D-glucopyranosyl-β-D-galactopyranoside
Timosaponinb-II β-D-Galactopyranoside, (3β,5β,25S)-26-(β-D-glucopyranosyloxy)-22-hydroxyfurostan-3-yl 2-O-β-D-glucopyranosyl- N1929 Timosaponin B2 |
Description | Timosaponin BII is an antioxidant and an anti-inflammatory agent. |
---|---|
Related Catalog | |
In Vitro | Timosaponin BII is a steroidal glycoside separated from Zhi Mu, is found to have the inhibitory activity against the proliferation of HL-60 (leukemic), Hela (cervix), HepG2 and Bel-7402 (liver), HT-29 (colon), and MDA-MB-468 (breast) human carcinoma cell lines with an IC50 value of 15.5 μg/mL in the HL-60 cells[1]. |
In Vivo | Rat retinas in model group and vehicle control group manifest an apparent up-regulation of BACE1 expression. Meanwhile, the level of malonaldehyde (MDA), Aβ1-40 and β-CTF are increased. However, when comparing with the vehicle control group, the retinas in Timosaponin-BII treated group showed significantly less BACE1 and accumulated less Aβ1-40 or β-CTF. It also showed significantly decreased level of MDA and prolonged partial thromboplastin time[2]. |
References |
Density | 1.5±0.1 g/cm3 |
---|---|
Boiling Point | 1033.6±65.0 °C at 760 mmHg |
Molecular Formula | C45H76O19 |
Molecular Weight | 921.073 |
Flash Point | 578.9±34.3 °C |
Exact Mass | 920.498108 |
PSA | 307.37000 |
LogP | 0.34 |
Vapour Pressure | 0.0±0.6 mmHg at 25°C |
Index of Refraction | 1.627 |