Timosaponin BII

Modify Date: 2025-08-21 09:46:55

Use of Timosaponin BII

Timosaponin BII is an antioxidant and an anti-inflammatory agent.

Name	Timosaponin B II
Synonym	More Synonyms

Description	Timosaponin BII is an antioxidant and an anti-inflammatory agent.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Cancer Research Areas >> Inflammation/Immunology Natural Products >> Saccharides and Glycosides
In Vitro	Timosaponin BII is a steroidal glycoside separated from Zhi Mu, is found to have the inhibitory activity against the proliferation of HL-60 (leukemic), Hela (cervix), HepG2 and Bel-7402 (liver), HT-29 (colon), and MDA-MB-468 (breast) human carcinoma cell lines with an IC50 value of 15.5 μg/mL in the HL-60 cells[1].
In Vivo	Rat retinas in model group and vehicle control group manifest an apparent up-regulation of BACE1 expression. Meanwhile, the level of malonaldehyde (MDA), Aβ1-40 and β-CTF are increased. However, when comparing with the vehicle control group, the retinas in Timosaponin-BII treated group showed significantly less BACE1 and accumulated less Aβ1-40 or β-CTF. It also showed significantly decreased level of MDA and prolonged partial thromboplastin time[2].
References	[1]. Guo J, et al. Cytotoxic activities of chemical constituents from rhizomes of Anemarrhena asphodeloides and their analogues. Arch Pharm Res. 2015;38(5):598-603. [2]. Huang JF, et al. Timosaponin-BII inhibits the up-regulation of BACE1 induced by ferric chloride in rat retina. BMC Complement Altern Med. 2012 Oct 22;12:189.

(3β,5β,25S)-26-(β-D-Glucopyranosyloxy)-22-hydroxyfurostan-3-yl 2-O-β-D-glucopyranosyl-β-D-galactopyranoside

Timosaponinb-II

β-D-Galactopyranoside, (3β,5β,25S)-26-(β-D-glucopyranosyloxy)-22-hydroxyfurostan-3-yl 2-O-β-D-glucopyranosyl-

N1929

Timosaponin B2

Get all suppliers and price by the below link:

Price: ￥1337/10 mM * 1 mL in DMSO

Reference only. check more Timosaponin BII price