- Shanghai Jizhi Biochemical Technology Co., Ltd
- China
- Product Name: Ophiopogonin B
- Price: ￥3528.0/5mg
- Purity: 98.0%
- Stocking Period: Inquiry
- Contact: Liu jia
- Dayang Chem (Hangzhou) Co., Ltd.
- China
- Product Name: ophiopogonin B
- Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
- Purity: 98.0%
- Stocking Period: Inquiry
- Contact: Ms Wang
38971-41-4
38971-41-4 structure
- Name: Ophiopogonin B
- Chemical Name: ophiopogonin B
- CAS Number: 38971-41-4
- Molecular Formula: C39H62O12
- Molecular Weight: 722.902
- Catalog: Signaling Pathways MAPK/ERK Pathway JNK
- Create Date: 2018-03-12 08:00:00
- Modify Date: 2024-01-05 13:17:40
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Ophiopogonin B induces the autophagy and apoptosis of colon cancer cells by activating JNK/c-Jun signaling pathway. Ophiopogonin B is a saponin compound isolated from Radix Ophiopogonjaponicus[1].
| Name | ophiopogonin B |
|---|---|
| Synonyms |
α-D-Galactopyranoside, (1β,3β,25R)-3-hydroxyspirost-5-en-1-yl 6-deoxy-2-O-(6-deoxy-α-L-mannopyranosyl)-
4-Octacosanone,24-hydroxy 24-hydroxy-4-octacosanone (1β,3β,25R)-3-Hydroxyspirost-5-en-1-yl 6-deoxy-2-O-(6-deoxy-α-L-mannopyranosyl)-α-D-galactopyranoside |
| Description | Ophiopogonin B induces the autophagy and apoptosis of colon cancer cells by activating JNK/c-Jun signaling pathway. Ophiopogonin B is a saponin compound isolated from Radix Ophiopogonjaponicus[1]. |
|---|---|
| Related Catalog | |
| Target |
JNK |
| In Vitro | Ophiopogonin B (0, 5, 10and 20 μM) suppresses the proliferation of HT-29 and HCT-116 cell lines through the G0/G1 phase cell cycle arrest[1]. Ophiopogonin B induces apoptosis by inhibiting the expression of Bax and cleaved caspase 3 and promoting the expression of Bcl-2. Treatment with Ophiopogonin B also increases the expression of Beclin 1 and the conversion of LC3I to LC3II with the activation of JNK/c-Jun signaling pathway[1]. |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 835.7±65.0 °C at 760 mmHg |
| Molecular Formula | C39H62O12 |
| Molecular Weight | 722.902 |
| Flash Point | 459.2±34.3 °C |
| Exact Mass | 722.424133 |
| PSA | 176.76000 |
| LogP | 5.63 |
| Vapour Pressure | 0.0±0.6 mmHg at 25°C |
| Index of Refraction | 1.604 |
| Hazard Codes | Xi |
|---|
|
~%
38971-41-4 |
| Literature: Watanabe, Yoshiaki; Sanada, Shuichi; Ida, Yoshiteru; Shoji, Junzo Chemical & Pharmaceutical Bulletin, 1984 , vol. 32, # 10 p. 3994 - 4002 |
|
~%
38971-41-4 |
| Literature: Watanabe, Yoshiaki; Sanada, Shuichi; Ida, Yoshiteru; Shoji, Junzo Chemical & Pharmaceutical Bulletin, 1984 , vol. 32, # 10 p. 3994 - 4002 |
| Precursor 1 | |
|---|---|
| DownStream 1 | |
