472-11-7

472-11-7 structure

Name: Ruscogenin
Chemical Name: Ruscogenin
CAS Number: 472-11-7
Molecular Formula: C₂₇H₄₂O₄
Molecular Weight: 430.62
Catalog: Biochemical Chinese herbal medicine ingredients
Create Date: 2018-04-08 08:00:00
Modify Date: 2024-01-02 18:04:25
Ruscogenin, an important steroid sapogenin derived from Ophiopogon japonicus, attenuates cerebral ischemia-induced blood-brain barrier dysfunction by suppressing TXNIP/NLRP3 inflammasome activation and the MAPK pathway and exerts significant anti-inflammatory and anti-thrombotic activities[1][2].

Name	Ruscogenin
Synonyms	(1β,3β,25R)-Spirost-5-ene-1,3-diol 25D-Spirost-5-ene-1\|A,3\|A-diol (25R)-Spirost-5-ene-1b,3b-diol (25R)-Spirost-5-ene-1β,3β-diol (1β,3β,25R)-Spirost-5-en-1,3-diol Spirost-5-en-1,3-diol, (1β,3β,25R)-

Description	Ruscogenin, an important steroid sapogenin derived from Ophiopogon japonicus, attenuates cerebral ischemia-induced blood-brain barrier dysfunction by suppressing TXNIP/NLRP3 inflammasome activation and the MAPK pathway and exerts significant anti-inflammatory and anti-thrombotic activities[1][2].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Immunology/Inflammation >> NOD-like Receptor (NLR)
References	[1]. Cao G, et al. Ruscogenin Attenuates Cerebral Ischemia-Induced Blood-Brain Barrier Dysfunction by Suppressing TXNIP/NLRP3 Inflammasome Activation and the MAPK Pathway. Int J Mol Sci. 2016 Aug 29;17(9). pii: E1418. [2]. Huang YL, et al. Possible mechanism of the anti-inflammatory activity of ruscogenin: role of intercellular adhesion molecule-1 and nuclear factor-kappaB. J Pharmacol Sci. 2008 Oct;108(2):198-205.

Hazard Codes	Xi
Safety Phrases	24/25
RIDADR	NONH for all modes of transport
HS Code	29389090

Precursor 4
17676-33-4 38971-41-4 125150-67-6 94898-61-0
DownStream 0