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91-85-0 63-56-9

91-85-0

91-85-0 structure
91-85-0 structure
  • Name: Thonzylamine
  • Chemical Name: N'-[(4-methoxyphenyl)methyl]-N,N-dimethyl-N'-pyrimidin-2-ylethane-1,2-diamine
  • CAS Number: 91-85-0
  • Molecular Formula: C16H22N4O
  • Molecular Weight: 286.37200
  • Catalog: API Antiallergic Antihistamine
  • Create Date: 2018-09-18 18:41:44
  • Modify Date: 2024-01-14 18:59:45
  • Thonzylamine is an orally active H1 histamine receptor antagonist, exhibits good antihistaminic and antianaphylactic properties. Thonzylamine can be used for the research of hypersensitivity diseases, nasal congestion, allergic conjunctivitis and other allergic diseases[1][2].
Name N'-[(4-methoxyphenyl)methyl]-N,N-dimethyl-N'-pyrimidin-2-ylethane-1,2-diamine
Synonyms thonzylamine
Tonzilamine
Neohetramine
Description Thonzylamine is an orally active H1 histamine receptor antagonist, exhibits good antihistaminic and antianaphylactic properties. Thonzylamine can be used for the research of hypersensitivity diseases, nasal congestion, allergic conjunctivitis and other allergic diseases[1][2].
Related Catalog
Target

H1 Receptor
References

[1]. Zhou S, et, al. Design, synthesis and biological activity of a novel ethylenediamine derivatives as H 1 receptor antagonists. Bioorg Med Chem. 2019 Dec 15; 27(24): 115127.

[2]. AARON TH, et, al. Neohetramine and thephorin; two new antihistaminic drugs. Can Med Assoc J. 1948 Nov; 59(5): 438-41.
Density 1.121g/cm3
Boiling Point 440.6ºC at 760 mmHg
Molecular Formula C16H22N4O
Molecular Weight 286.37200
Flash Point 220.3ºC
Exact Mass 286.17900
PSA 41.49000
LogP 2.05340
Index of Refraction 1.584

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UV8575000
CHEMICAL NAME :
Pyrimidine, 2-((2-(dimethylamino)ethyl)(p-methoxybenzyl)amino)-
CAS REGISTRY NUMBER :
91-85-0
BEILSTEIN REFERENCE NO. :
0284655
LAST UPDATED :
199612
DATA ITEMS CITED :
5
MOLECULAR FORMULA :
C16-H22-N4-O
MOLECULAR WEIGHT :
286.42
WISWESSER LINE NOTATION :
T6N CNJ BN1R DO1&2N1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - woman
DOSE/DURATION :
2 mg/kg
TOXIC EFFECTS :
Behavioral - general anesthetic Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - cyanosis
REFERENCE :
JOALAS Journal of Allergy. (St. Louis, MO) V.1-47, 1929-71. For publisher information, see JACIBY. Volume(issue)/page/year: 19,313,1948
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
245 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 66,512,1947
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
119 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 66,512,1947
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
493 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 66,512,1947 ** REPRODUCTIVE DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intramuscular
DOSE :
50 mg/kg
SEX/DURATION :
female 5 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea)
REFERENCE :
PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 100,555,1959
HS Code 2933599090
2393-23-9 structure

2393-23-9

~%

91-85-0 structure

91-85-0
Literature: Farmaco, Edizione Scientifica, , vol. 39, # 3 p. 189 - 199
6957-21-7 structure

6957-21-7
107-99-3 structure

107-99-3

~%

91-85-0 structure

91-85-0
Literature: Takamine Kenkyusho Nenpo, , vol. 4, p. 36,38 Chem.Abstr., , p. 11665 DE823598 , ; DRP/DRBP Org.Chem. US2465865 , ; Yakugaku Zasshi, , vol. 72, p. 1447,1450 Chem.Abstr., , p. 8080
90042-89-0 structure

90042-89-0

~%

91-85-0 structure

91-85-0
Literature: Farmaco, Edizione Scientifica, , vol. 39, # 3 p. 189 - 199
1722-12-9 structure

1722-12-9
65875-39-0 structure

65875-39-0

~%

91-85-0 structure

91-85-0
Literature: Yakugaku Zasshi, , vol. 71, p. 1316 Chem.Abstr., , p. 8123
21244-39-3 structure

21244-39-3

~%

91-85-0 structure

91-85-0
Literature: Yakugaku Zasshi, , vol. 72, p. 1447,1450 Chem.Abstr., , p. 8080
91907-70-9 structure

91907-70-9

~%

91-85-0 structure

91-85-0
Literature: Yakugaku Zasshi, , vol. 71, p. 1316 Chem.Abstr., , p. 8123
HS Code 2933599090
Summary 2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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