Thonzylamine

Modify Date: 2026-07-16 15:26:56

Thonzylamine structure	Common Name	Thonzylamine
	CAS Number	91-85-0	Molecular Weight	286.37200
	Density	1.121g/cm3	Boiling Point	440.6ºC at 760 mmHg
	Molecular Formula	C₁₆H₂₂N₄O	Melting Point	N/A
	MSDS	N/A	Flash Point	220.3ºC

Use of Thonzylamine

Thonzylamine is an orally active H1 histamine receptor antagonist, exhibits good antihistaminic and antianaphylactic properties. Thonzylamine can be used for the research of hypersensitivity diseases, nasal congestion, allergic conjunctivitis and other allergic diseases[1][2].

This table lists Chinese names, IUPAC names and various aliases of this chemical substance.

Name	N'-[(4-methoxyphenyl)methyl]-N,N-dimethyl-N'-pyrimidin-2-ylethane-1,2-diamine
Synonym	More Synonyms

This table contains bioactivity, target information and biological‑assay experimental data of this compound.

Description	Thonzylamine is an orally active H1 histamine receptor antagonist, exhibits good antihistaminic and antianaphylactic properties. Thonzylamine can be used for the research of hypersensitivity diseases, nasal congestion, allergic conjunctivitis and other allergic diseases[1][2].
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor Research Areas >> Inflammation/Immunology Signaling Pathways >> GPCR/G Protein >> Histamine Receptor
Target	H1 Receptor
References	[1]. Zhou S, et, al. Design, synthesis and biological activity of a novel ethylenediamine derivatives as H 1 receptor antagonists. Bioorg Med Chem. 2019 Dec 15; 27(24): 115127. [2]. AARON TH, et, al. Neohetramine and thephorin; two new antihistaminic drugs. Can Med Assoc J. 1948 Nov; 59(5): 438-41.

This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.

Density	1.121g/cm3
Boiling Point	440.6ºC at 760 mmHg
Molecular Formula	C₁₆H₂₂N₄O
Molecular Weight	286.37200
Flash Point	220.3ºC
Exact Mass	286.17900
PSA	41.49000
LogP	2.05340
Index of Refraction	1.584
InChIKey	GULNIHOSWFYMRN-UHFFFAOYSA-N
SMILES	COc1ccc(CN(CCN(C)C)c2ncccn2)cc1

This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UV8575000

CHEMICAL NAME :: Pyrimidine, 2-((2-(dimethylamino)ethyl)(p-methoxybenzyl)amino)-

CAS REGISTRY NUMBER :: 91-85-0

BEILSTEIN REFERENCE NO. :: 0284655

LAST UPDATED :: 199612

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C16-H22-N4-O

MOLECULAR WEIGHT :: 286.42

WISWESSER LINE NOTATION :: T6N CNJ BN1R DO1&2N1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 2 mg/kg

TOXIC EFFECTS :: Behavioral - general anesthetic Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - cyanosis

REFERENCE :: JOALAS Journal of Allergy. (St. Louis, MO) V.1-47, 1929-71. For publisher information, see JACIBY. Volume(issue)/page/year: 19,313,1948

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 245 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 66,512,1947

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 119 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 66,512,1947

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 493 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 66,512,1947 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intramuscular

DOSE :: 50 mg/kg

SEX/DURATION :: female 5 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea)

REFERENCE :: PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 100,555,1959

This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.

HS Code	2933599090

This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.

4-Methoxybenzylamine

CAS#:2393-23-9

Thonzylamine

CAS#:91-85-0

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Literature: Farmaco, Edizione Scientifica, , vol. 39, # 3 p. 189 - 199

2-Pyrimidinamin...

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2-Chloroethyldi...

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Literature: Takamine Kenkyusho Nenpo, , vol. 4, p. 36,38 Chem.Abstr., , p. 11665 DE823598 , ; DRP/DRBP Org.Chem. US2465865 , ; Yakugaku Zasshi, , vol. 72, p. 1447,1450 Chem.Abstr., , p. 8080

4,6-dichloro-N-...

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Literature: Farmaco, Edizione Scientifica, , vol. 39, # 3 p. 189 - 199

chloropyrimidine

CAS#:1722-12-9

N'-(4-methoxy-b...

CAS#:65875-39-0

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Literature: Yakugaku Zasshi, , vol. 71, p. 1316 Chem.Abstr., , p. 8123

N/A

CAS#:21244-39-3

Thonzylamine

CAS#:91-85-0

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Literature: Yakugaku Zasshi, , vol. 72, p. 1447,1450 Chem.Abstr., , p. 8080

N'-(4-methoxy-b...

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Literature: Yakugaku Zasshi, , vol. 71, p. 1316 Chem.Abstr., , p. 8123

This table lists upstream starting materials and downstream derivative products related to this chemical.

Precursor 6
CAS#:2393-23-9 4-Methoxybenzylamine CAS#:6957-21-7 2-Pyrimidinamin... CAS#:107-99-3 2-Chloroethyldi... CAS#:90042-89-0 4,6-dichloro-N-...
CAS#:1722-12-9 chloropyrimidine CAS#:65875-39-0 N'-(4-methoxy-b...
DownStream 2
CAS#:68303-34-4 N-[2-(dimethyla... CAS#:726-18-1 Benzene,1,1'-me...

This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.

HS Code	2933599090
Summary	2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

This table contains target information, in‑vitro & in‑vivo assay data for this compound.

Name: Antiviral activity against SARS-CoV-2 (USA-WA1/2020 strain) measured by imaging in HR...
Source: ChEMBL
Target: Severe acute respiratory syndrome coronavirus 2
External Id: CHEMBL4303810

Name: NCATS Human Liver Microsomal (HLM) Stability Profiling
Source: NCGC
Target: N/A
External Id: ADME-HLM1

Name: Enzymatic assay of human HDAC6 with commercial peptide substrate
Source: ChEMBL
Target: Histone deacetylase 6
External Id: CHEMBL4808149

Name: uHTS identification of small molecule modulators of Rev-erb Alpha.
Source: Burnham Center for Chemical Genomics
Target: N/A
External Id: SBCCG-A1016-RevErbaLBD-Primary-Assay

Name: Enzymatic assay of human HDAC6 with custom peptide substrate
Source: ChEMBL
Target: Histone deacetylase 6
External Id: CHEMBL4808150

Name: Screen for inhibitors of RMI FANCM (MM2) intereaction
Source: 11908
Target: N/A
External Id: RMI-FANCM-MM2

Name: Phenotypic Assay to Identify Small Molecules that Upregulate Production of hCFTR in H...
Source: Southern Research Institute
Target: CFTR
External Id: CF Folding

Name: The chemical genetic matrix (CGM) dataset as reported in Wildenhain et al. (2015) Pre...
Source: 11924
Target: N/A
External Id: CGM data for Cell Systems paper Dec 2015

Total 8, Current Page 1 of 1

This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.

thonzylamine

Tonzilamine

Neohetramine

This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.

Q: What is the molecular formula of N'-[(4-methoxyphenyl)methyl]-N,N-dimethyl-N'-pyrimidin-2-ylethane-1,2-diamine?

A: Molecular formula of N'-[(4-methoxyphenyl)methyl]-N,N-dimethyl-N'-pyrimidin-2-ylethane-1,2-diamine is C16H22N4O.

Q: What English synonyms does N'-[(4-methoxyphenyl)methyl]-N,N-dimethyl-N'-pyrimidin-2-ylethane-1,2-diamine have?

A: English synonyms of N'-[(4-methoxyphenyl)methyl]-N,N-dimethyl-N'-pyrimidin-2-ylethane-1,2-diamine: thonzylamine, Tonzilamine, Neohetramine.

Q: What are the upstream materials of N'-[(4-methoxyphenyl)methyl]-N,N-dimethyl-N'-pyrimidin-2-ylethane-1,2-diamine?

A: Related upstream materials(CAS) of N'-[(4-methoxyphenyl)methyl]-N,N-dimethyl-N'-pyrimidin-2-ylethane-1,2-diamine: 2393-23-9;6957-21-7;107-99-3;90042-89-0;1722-12-9;65875-39-0.

Q: What is the polar surface area (PSA) of N'-[(4-methoxyphenyl)methyl]-N,N-dimethyl-N'-pyrimidin-2-ylethane-1,2-diamine?

A: Polar surface area (PSA) of N'-[(4-methoxyphenyl)methyl]-N,N-dimethyl-N'-pyrimidin-2-ylethane-1,2-diamine is 41.49000.

Q: What is the boiling point of N'-[(4-methoxyphenyl)methyl]-N,N-dimethyl-N'-pyrimidin-2-ylethane-1,2-diamine?

A: Boiling point of N'-[(4-methoxyphenyl)methyl]-N,N-dimethyl-N'-pyrimidin-2-ylethane-1,2-diamine is 440.6ºC at 760 mmHg.

Q: What are the uses of N'-[(4-methoxyphenyl)methyl]-N,N-dimethyl-N'-pyrimidin-2-ylethane-1,2-diamine?

A: Main uses of N'-[(4-methoxyphenyl)methyl]-N,N-dimethyl-N'-pyrimidin-2-ylethane-1,2-diamine: Thonzylamine is an orally active H1 histamine receptor antagonist, exhibits good antihistaminic and antianaphylactic properties. Thonzylamine can be used for the research of hypersensitivity diseases, nasal congestion, allergic conjunctivitis and other allergic diseases[1][2].

Q: What is the CAS number of N'-[(4-methoxyphenyl)methyl]-N,N-dimethyl-N'-pyrimidin-2-ylethane-1,2-diamine?

A: CAS number of N'-[(4-methoxyphenyl)methyl]-N,N-dimethyl-N'-pyrimidin-2-ylethane-1,2-diamine is 91-85-0.

Q: What is the InChIKey of N'-[(4-methoxyphenyl)methyl]-N,N-dimethyl-N'-pyrimidin-2-ylethane-1,2-diamine?

A: InChIKey of N'-[(4-methoxyphenyl)methyl]-N,N-dimethyl-N'-pyrimidin-2-ylethane-1,2-diamine is GULNIHOSWFYMRN-UHFFFAOYSA-N.

Q: What is the English name of N'-[(4-methoxyphenyl)methyl]-N,N-dimethyl-N'-pyrimidin-2-ylethane-1,2-diamine?

A: The English name of N'-[(4-methoxyphenyl)methyl]-N,N-dimethyl-N'-pyrimidin-2-ylethane-1,2-diamine is N'-[(4-methoxyphenyl)methyl]-N,N-dimethyl-N'-pyrimidin-2-ylethane-1,2-diamine.

Q: What is the SMILES notation of N'-[(4-methoxyphenyl)methyl]-N,N-dimethyl-N'-pyrimidin-2-ylethane-1,2-diamine?

A: SMILES notation of N'-[(4-methoxyphenyl)methyl]-N,N-dimethyl-N'-pyrimidin-2-ylethane-1,2-diamine is COc1ccc(CN(CCN(C)C)c2ncccn2)cc1.

This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.

Shanghai Nianxing Industrial Co., Ltd

Dayang Chem (Hangzhou) Co., Ltd.

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Thonzylamine
Price: Check
Purity: 99.45%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: thonzylamine
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

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