Thonzylamine

Modify Date: 2024-01-14 18:59:45

Thonzylamine Structure
Thonzylamine structure
 Common Name Thonzylamine
CAS Number 91-85-0 Molecular Weight 286.37200
Density 1.121g/cm3 Boiling Point 440.6ºC at 760 mmHg
Molecular Formula C16H22N4O Melting Point N/A
MSDS N/A Flash Point 220.3ºC

 Use of Thonzylamine


Thonzylamine is an orally active H1 histamine receptor antagonist, exhibits good antihistaminic and antianaphylactic properties. Thonzylamine can be used for the research of hypersensitivity diseases, nasal congestion, allergic conjunctivitis and other allergic diseases[1][2].

 Names

Name N'-[(4-methoxyphenyl)methyl]-N,N-dimethyl-N'-pyrimidin-2-ylethane-1,2-diamine
Synonym More Synonyms

 Thonzylamine Biological Activity

Description Thonzylamine is an orally active H1 histamine receptor antagonist, exhibits good antihistaminic and antianaphylactic properties. Thonzylamine can be used for the research of hypersensitivity diseases, nasal congestion, allergic conjunctivitis and other allergic diseases[1][2].
Related Catalog
Target

H1 Receptor

References

[1]. Zhou S, et, al. Design, synthesis and biological activity of a novel ethylenediamine derivatives as H 1 receptor antagonists. Bioorg Med Chem. 2019 Dec 15; 27(24): 115127.

[2]. AARON TH, et, al. Neohetramine and thephorin; two new antihistaminic drugs. Can Med Assoc J. 1948 Nov; 59(5): 438-41.

 Chemical & Physical Properties

Density 1.121g/cm3
Boiling Point 440.6ºC at 760 mmHg
Molecular Formula C16H22N4O
Molecular Weight 286.37200
Flash Point 220.3ºC
Exact Mass 286.17900
PSA 41.49000
LogP 2.05340
Index of Refraction 1.584

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UV8575000
CHEMICAL NAME :
Pyrimidine, 2-((2-(dimethylamino)ethyl)(p-methoxybenzyl)amino)-
CAS REGISTRY NUMBER :
91-85-0
BEILSTEIN REFERENCE NO. :
0284655
LAST UPDATED :
199612
DATA ITEMS CITED :
5
MOLECULAR FORMULA :
C16-H22-N4-O
MOLECULAR WEIGHT :
286.42
WISWESSER LINE NOTATION :
T6N CNJ BN1R DO1&2N1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - woman
DOSE/DURATION :
2 mg/kg
TOXIC EFFECTS :
Behavioral - general anesthetic Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - cyanosis
REFERENCE :
JOALAS Journal of Allergy. (St. Louis, MO) V.1-47, 1929-71. For publisher information, see JACIBY. Volume(issue)/page/year: 19,313,1948
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
245 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 66,512,1947
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
119 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 66,512,1947
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
493 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 66,512,1947 ** REPRODUCTIVE DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intramuscular
DOSE :
50 mg/kg
SEX/DURATION :
female 5 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea)
REFERENCE :
PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 100,555,1959

 Safety Information

HS Code 2933599090

 Synthetic Route

4-Methoxybenzylamine structure

4-Methoxybenzylamine

CAS#:2393-23-9

~%

Thonzylamine Structure

Thonzylamine

CAS#:91-85-0

Literature: Farmaco, Edizione Scientifica, , vol. 39, # 3 p. 189 - 199
2-Pyrimidinamine,N-[(4-methoxyphenyl)methyl]- structure

2-Pyrimidinamin...

CAS#:6957-21-7

2-Chloroethyldimethylamine structure

2-Chloroethyldi...

CAS#:107-99-3

~%

Thonzylamine Structure

Thonzylamine

CAS#:91-85-0

Literature: Takamine Kenkyusho Nenpo, , vol. 4, p. 36,38 Chem.Abstr., , p. 11665 DE823598 , ; DRP/DRBP Org.Chem. US2465865 , ; Yakugaku Zasshi, , vol. 72, p. 1447,1450 Chem.Abstr., , p. 8080
4,6-dichloro-N-[(4-methoxyphenyl)methyl]pyrimidin-2-amine structure

4,6-dichloro-N-...

CAS#:90042-89-0

~%

Thonzylamine Structure

Thonzylamine

CAS#:91-85-0

Literature: Farmaco, Edizione Scientifica, , vol. 39, # 3 p. 189 - 199
chloropyrimidine structure

chloropyrimidine

CAS#:1722-12-9

N'-(4-methoxy-benzyl)-N,N-dimethyl-ethylenediamine structure

N'-(4-methoxy-b...

CAS#:65875-39-0

~%

Thonzylamine Structure

Thonzylamine

CAS#:91-85-0

Literature: Yakugaku Zasshi, , vol. 71, p. 1316 Chem.Abstr., , p. 8123
N/A structure

N/A

CAS#:21244-39-3

~%

Thonzylamine Structure

Thonzylamine

CAS#:91-85-0

Literature: Yakugaku Zasshi, , vol. 72, p. 1447,1450 Chem.Abstr., , p. 8080
N'-(4-methoxy-benzylidene)-N,N-dimethyl-ethylenediamine structure

N'-(4-methoxy-b...

CAS#:91907-70-9

~%

Thonzylamine Structure

Thonzylamine

CAS#:91-85-0

Literature: Yakugaku Zasshi, , vol. 71, p. 1316 Chem.Abstr., , p. 8123

 Customs

HS Code 2933599090
Summary 2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Synonyms

thonzylamine
Tonzilamine
Neohetramine
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Chemsrc provides Thonzylamine(CAS#:91-85-0) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of Thonzylamine are included as well.>> amp version: Thonzylamine

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