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91-85-0生产厂家

91-85-0价格

91-85-0

91-85-0结构式
91-85-0结构式

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中文名 松齐拉敏
英文名 N'-[(4-methoxyphenyl)methyl]-N,N-dimethyl-N'-pyrimidin-2-ylethane-1,2-diamine
英文别名 thonzylamine
Tonzilamine
Neohetramine
描述 Thonzylamine 是一种具有口服活性的 H1 组胺受体拮抗剂,具有良好的抗组胺和抗过敏特性。Thonzylamine 可用于过敏性疾病,鼻充血,过敏性结膜炎和其他过敏性疾病的研究。
相关类别
靶点

H1 Receptor

参考文献

[1]. Zhou S, et, al. Design, synthesis and biological activity of a novel ethylenediamine derivatives as H 1 receptor antagonists. Bioorg Med Chem. 2019 Dec 15; 27(24): 115127.

[2]. AARON TH, et, al. Neohetramine and thephorin; two new antihistaminic drugs. Can Med Assoc J. 1948 Nov; 59(5): 438-41.

密度 1.121g/cm3
沸点 440.6ºC at 760 mmHg
分子式 C16H22N4O
分子量 286.37200
闪点 220.3ºC
精确质量 286.17900
PSA 41.49000
LogP 2.05340
折射率 1.584
储存条件 2-8°C, 惰性气体

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UV8575000
CHEMICAL NAME :
Pyrimidine, 2-((2-(dimethylamino)ethyl)(p-methoxybenzyl)amino)-
CAS REGISTRY NUMBER :
91-85-0
BEILSTEIN REFERENCE NO. :
0284655
LAST UPDATED :
199612
DATA ITEMS CITED :
5
MOLECULAR FORMULA :
C16-H22-N4-O
MOLECULAR WEIGHT :
286.42
WISWESSER LINE NOTATION :
T6N CNJ BN1R DO1&2N1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - woman
DOSE/DURATION :
2 mg/kg
TOXIC EFFECTS :
Behavioral - general anesthetic Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - cyanosis
REFERENCE :
JOALAS Journal of Allergy. (St. Louis, MO) V.1-47, 1929-71. For publisher information, see JACIBY. Volume(issue)/page/year: 19,313,1948
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
245 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 66,512,1947
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
119 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 66,512,1947
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
493 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 66,512,1947 ** REPRODUCTIVE DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intramuscular
DOSE :
50 mg/kg
SEX/DURATION :
female 5 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea)
REFERENCE :
PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 100,555,1959

海关编码 2933599090

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91-85-0结构式

91-85-0

文献:Farmaco, Edizione Scientifica, , vol. 39, # 3 p. 189 - 199

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文献:Takamine Kenkyusho Nenpo, , vol. 4, p. 36,38 Chem.Abstr., , p. 11665 DE823598 , ; DRP/DRBP Org.Chem. US2465865 , ; Yakugaku Zasshi, , vol. 72, p. 1447,1450 Chem.Abstr., , p. 8080

~%

91-85-0结构式

91-85-0

文献:Farmaco, Edizione Scientifica, , vol. 39, # 3 p. 189 - 199

~%

91-85-0结构式

91-85-0

文献:Yakugaku Zasshi, , vol. 71, p. 1316 Chem.Abstr., , p. 8123

~%

91-85-0结构式

91-85-0

文献:Yakugaku Zasshi, , vol. 72, p. 1447,1450 Chem.Abstr., , p. 8080

~%

91-85-0结构式

91-85-0

文献:Yakugaku Zasshi, , vol. 71, p. 1316 Chem.Abstr., , p. 8123
海关编码 2933599090
中文概述 2933599090. 其他结构上有嘧啶环的化合物(包括其他结构上有哌嗪环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素 品名, 成分含量, 用途, 乌洛托品请注明外观, 6-己内酰胺请注明外观, 签约日期
Summary 2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%