23567-23-9

23567-23-9 structure

Name: Procyanidin B3
Chemical Name: procyanidin B3
CAS Number: 23567-23-9
Molecular Formula: C₃₀H₂₆O₁₂
Molecular Weight: 578.520
Catalog: Biochemical Natural product
Create Date: 2018-09-18 18:34:43
Modify Date: 2024-01-08 10:33:46
Procyanidin B3 is a natural product, acts as a specific HAT inhibitor, binds to the other site of p300 instead of the active site, selectively inhibits p300-mediated androgen receptor acetylation. Procyanidin B3 has no effect on HDAC or HMT (histone methyltransferase)[1].

Name	procyanidin B3
Synonyms	Proanthocyanidin B3 Procyanidin B2 (2R,2'R,3R,3'R,4R)-2,2'-Bis(3,4-dihydroxyphenyl)-3,3',4,4'-tetrahydro-2H,2'H-4,8'-bichromene-3,3',5,5',7,7'-hexol (2R,3S)-2-(3,4-dihydroxyphenyl)-8-[(2R,3S,4S)-2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-3,4-dihydro-2H-chromen-4-yl]-3,4-dihydro-2H-chromene-3,5,7-triol 4,8"-Bi-[(+)-epicatechin] Procyanidin B-3 Proanthocyanidin UNII-L88HKE854X 2,3-trans-proanthocyanidin [4,8'-Bi-2H-1-benzopyran]-3,3',5,5',7,7'-hexol, 2,2'-bis(3,4-dihydroxyphenyl)-3,3',4,4'-tetrahydro-, (2R,2'R,3R,3'R,4R)-

Description	Procyanidin B3 is a natural product, acts as a specific HAT inhibitor, binds to the other site of p300 instead of the active site, selectively inhibits p300-mediated androgen receptor acetylation. Procyanidin B3 has no effect on HDAC or HMT (histone methyltransferase)[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Epigenetics >> Histone Acetyltransferase
Target	p300[1]
References	[1]. Choi KC, et al. Procyanidin B3, an inhibitor of histone acetyltransferase, enhances the action of antagonist for prostate cancer cells via inhibition of p300-dependent acetylation of androgen receptor. Biochem J. 2011 Jan 1;433(1):235-44.