Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: (2R,4R)-METHYL 4-HYDROXYPYRROLIDINE-2-CARBOXYLATE HYDROCHLORIDE
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114676-59-4

114676-59-4 structure

Name: D-Proline, 4-hydroxy-, methyl ester hydrochloride
Chemical Name: D-Proline, 4-hydroxy-, methyl ester, (Hydrochloride) (1:1), (4R)
CAS Number: 114676-59-4
Molecular Formula: C₆H₁₂ClNO₃
Molecular Weight: 181.617
Catalog: Signaling Pathways Antibody-drug Conjugate ADC Linker
Create Date: 2018-08-02 15:50:13
Modify Date: 2026-07-03 17:16:14
D-Proline, 4-hydroxy-, methyl ester hydrochloride is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). D-Proline, 4-hydroxy-, methyl ester hydrochloride is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1][2

Name	D-Proline, 4-hydroxy-, methyl ester, (Hydrochloride) (1:1), (4R)
Synonyms	D-Proline, 4-hydroxy-, methyl ester, (4R)-, hydrochloride (1:1) D-Proline, 4-hydroxy-, methyl ester (hydrochloride) (4R)-4-hydroxy-D-Proline methyl ester hydrochloride (1:1) Methyl (4R)-4-hydroxy-L-prolinate hydrochloride (1:1) Cis-4-Hydroxy-D-proline Methyl ester HCl Methyl (4R)-4-hydroxy-D-prolinate hydrochloride (1:1) (2R,4R)-4-Hydroxypyrrolidine-2-carboxylic acid methyl ester hydrochloride Methyl (2R,4R)-4-hydroxypyrrolidine-2-cboxylate hydrochloride CIS-4-HYDROXY-D-PROLINE METHYL ESTER D-Proline, 4-Hydroxy L-Proline, 4-hydroxy-, methyl ester, (4R)-, hydrochloride (1:1) Cis-D-Hyp-OMe.HCl Cis-4-hydroxy-proline Methyl ester hydrochloride -D Cis-D-Hyp-OMe.HC Methyl 4-hydroxypyrrolidine-2-cboxylate HCl D-Proline, 4-hydroxy-, methyl ester, hydrochloride (1:1), (4 cis-4-hydroxy-D-proline methyl ester hydrochloride (2R,4R)-cis-4-hydroxy-D-proline methyl ester hydrochloride Trans-4-hydroxy-L-proline methyl ester hydrochloride (4R)-4-Hydroxy-D-proline methyl ester HCl D-Proline, 4-hydroxy-, methyl ester, hydrochloride (1 (2R,4R)-4-Hydroxypyrrolidine-2-cboxylic acid methyl ester hydrochloride D-Proline, 4-hydroxy-, Methyl ester, hydrochloride, (4R) methyl cis 4-hydroxyl-D-proline (2R,4R)-4-Hydroxy-2-(methoxycbonyl)pyrrolidine hydrochloride, cis-4-Hydroxy-D-proline methyl ester hydrochloride (2R,4R)-Methyl 4-hydroxypyrrolidine-2-carboxylate hydrochloride D-Proline, 4-hydroxy-, methyl ester, hydrochloride (1:1), (4R) (2R,4R)-methyl 4-hydroxypyrrolidine-2-cboxylate Hydrochloride/CIS-4-HYDROXY-D-PROLINE METHYL ESTER Hydrochloride Methyl cis-4-Hydroxy-D-proline Hydrochloride

Description	D-Proline, 4-hydroxy-, methyl ester hydrochloride is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). D-Proline, 4-hydroxy-, methyl ester hydrochloride is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1][2
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker Signaling Pathways >> PROTAC >> PROTAC Linker
Target	Non-cleavable
In Vitro	ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].
References	[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337. [2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.