26839-75-8

26839-75-8 structure

Name: Timolol
Chemical Name: (S)-timolol (anhydrous)
CAS Number: 26839-75-8
Molecular Formula: C₁₃H₂₄N₄O₃S
Molecular Weight: 316.42000
Catalog: API Circulatory system medication Antiarrhythmic drug
Create Date: 2018-06-23 13:22:38
Modify Date: 2024-01-04 13:05:56
Timolol is a β-blocker available for both topical and systemic administration. Topical Timolol is primarily used to reduce intraocular pressure with open-angle glaucoma and ocular hypertension. Timolol can also be used for the research of infantile hemangiomas, hypertension, myocardial infarction, migraine prophylaxis, and atrial fibrillation.Timolol also has cardioprotective effect[1][2].

Name	(S)-timolol (anhydrous)
Synonyms	(S)-thymolol timolol Istalol (S)-timolol (2S)-1-(tert-butylamino)-3-[(4-morpholin-4-yl-1,2,5-thiadiazol-3-yl)oxy]propan-2-ol Optimol (S)-(-)-3-(3-tert-butylamino-2-hydroxypropoxy)-4-(N-morpholino)-1,2,5-thiadiazole Timacar (S)-(-)-(1-tert-butylamino)-3-(4-morpholino-1,2,5-thiadiazol-3-yloxy)-2-propanol Timoptic Blocadren S(-)-Timolol maleate Betimol Timoptol EINECS 248-032-6 MFCD00864565 Timopic

Description	Timolol is a β-blocker available for both topical and systemic administration. Topical Timolol is primarily used to reduce intraocular pressure with open-angle glaucoma and ocular hypertension. Timolol can also be used for the research of infantile hemangiomas, hypertension, myocardial infarction, migraine prophylaxis, and atrial fibrillation.Timolol also has cardioprotective effect[1][2].
Related Catalog	Research Areas >> Cancer Research Areas >> Cardiovascular Disease Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor Research Areas >> Inflammation/Immunology
In Vitro	Timolol can significantly prevent the increased lipid peroxidation level of the heart from diabetic rats. Timolol can induce a well-balanced ratio between oxidative stress and antioxidant defense system in the diabetic animals, can have an important cardioprotection against diabetes-induced ERS and associated apoptotic effects[3].
In Vivo	Timolol has a cardioprotective effect via inhibition of ERS response in diabetic rats[3]. Animal Model: Experimental diabetes model: 3-month old male Wistar rats[3]. Dosage: 5 mg/kg Administration: Timolol (5 mg/kg daily for 12-week) Result: Showed cardioprotective effect.
References	[1]. James Barnes; Majid Moshirfar. Timolol. [2]. E. Ansari, et al. Treatment of open-angle glaucoma and ocular hypertension with preservative-free tafuprost/timolol fxed-dose combination therapy: 6 case reports and clinical outcomes. BMC Ophthalmol. 2022 Apr 2;22(1):152. [3]. Figen Amber Cicek, et al. Beta-blocker timolol alleviates hyperglycemia-induced cardiac damage via inhibition of endoplasmic reticulum stress. J Bioenerg Biomembr

Density	1.224 g/cm3
Boiling Point	487.2ºC at 760 mmHg
Melting Point	71.5 - 72.5ºC
Molecular Formula	C₁₃H₂₄N₄O₃S
Molecular Weight	316.42000
Flash Point	248.5ºC
Exact Mass	316.15700
PSA	107.98000
LogP	0.95840
Vapour Pressure	2.62E-10mmHg at 25°C
Index of Refraction	1.548

Precursor 9
56526-15-9 30165-97-0 30165-96-9 194861-99-9
75-64-9 58827-68-2 30315-46-9 69500-53-4
29023-48-1
DownStream 1
26921-17-5

26839-75-8	47148-57-2
59697-06-2	26839-76-9
91524-16-2	57073-55-9
26921-17-5	106351-79-5
26839-77-0	30418-38-3