29110-47-2
29110-47-2 structure
- Name: Guanfacine
- Chemical Name: N-(diaminomethylidene)-2-(2,6-dichlorophenyl)acetamide
- CAS Number: 29110-47-2
- Molecular Formula: C9H9Cl2N3O
- Molecular Weight: 246.093
- Catalog: API Circulatory system medication Antihypertensive drug
- Create Date: 2018-08-08 16:55:56
- Modify Date: 2025-08-20 11:58:07
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Guanfacine is a selective α2A receptor agonist.Target: α2A ReceptorGuanfacine is a sympatholytic. It is a selective α2A receptor agonist. These receptors are concentrated heavily in the prefrontal cortex and the locus coeruleus, with the potential to improve attention resulting from interaction with receptors in the former. Guanfacine lowers both systolic and diastolic blood pressure by activating the central nervous system α2A norepinephrine autoreceptors, which results in reduced peripheral sympathetic outflow and thus a reduction in peripheral sympathetic tone [1, 2].
| Name | N-(diaminomethylidene)-2-(2,6-dichlorophenyl)acetamide |
|---|---|
| Synonyms |
Intuniv
Guanfacine Guanfacina [INN-Spanish] [(2,6-Dichlorophenyl)acetyl]guanidine Guanfacine [INN:BAN] Benzeneacetamide, N-(aminoiminomethyl)-2,6-dichloro- N-amidino-2-(2,6-dichlorophenyl)acetamide N-Carbamimidoyl-2-(2,6-dichlorophenyl)acetamide Estulic Lon798 Guanfacina N-(aminoiminomethyl)-2,6-dichlorobenzeneacetamide Guanfacinum Guanfacinum [INN-Latin] BS 100-141 Tenex |
| Description | Guanfacine is a selective α2A receptor agonist.Target: α2A ReceptorGuanfacine is a sympatholytic. It is a selective α2A receptor agonist. These receptors are concentrated heavily in the prefrontal cortex and the locus coeruleus, with the potential to improve attention resulting from interaction with receptors in the former. Guanfacine lowers both systolic and diastolic blood pressure by activating the central nervous system α2A norepinephrine autoreceptors, which results in reduced peripheral sympathetic outflow and thus a reduction in peripheral sympathetic tone [1, 2]. |
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| Related Catalog | |
| References |
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 424.9ºC at 760 mmHg |
| Melting Point | 227-230?C |
| Molecular Formula | C9H9Cl2N3O |
| Molecular Weight | 246.093 |
| Flash Point | 210.8ºC |
| Exact Mass | 245.012268 |
| PSA | 78.97000 |
| LogP | 1.12 |
| Vapour Pressure | 2E-07mmHg at 25°C |
| Index of Refraction | 1.635 |
| Storage condition | Refrigerator |
| HS Code | 2925290090 |
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|
~%
29110-47-2 |
| Literature: Dodd, Dharmpal S.; Zhao, Yufen Tetrahedron Letters, 2001 , vol. 42, # 7 p. 1259 - 1262 |
|
~%
29110-47-2 |
| Literature: Bream; Lauener; Picard; Scholtysik; White Arzneimittel-Forschung/Drug Research, 1975 , vol. 25, # 10 p. 1477 - 1482 |
|
~%
29110-47-2 |
| Literature: Bream; Lauener; Picard; Scholtysik; White Arzneimittel-Forschung/Drug Research, 1975 , vol. 25, # 10 p. 1477 - 1482 |
| Precursor 5 | |
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| DownStream 0 | |
| HS Code | 2925290090 |
|---|---|
| Summary | 2925290090 other imines and their derivatives; salts thereof。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0% |