Guanfacine
Modify Date: 2024-01-02 11:56:54
Guanfacine structure
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Common Name | Guanfacine | ||
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| CAS Number | 29110-47-2 | Molecular Weight | 246.093 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 424.9ºC at 760 mmHg | |
| Molecular Formula | C9H9Cl2N3O | Melting Point | 227-230?C | |
| MSDS | N/A | Flash Point | 210.8ºC | |
Use of GuanfacineGuanfacine is a selective α2A receptor agonist.Target: α2A ReceptorGuanfacine is a sympatholytic. It is a selective α2A receptor agonist. These receptors are concentrated heavily in the prefrontal cortex and the locus coeruleus, with the potential to improve attention resulting from interaction with receptors in the former. Guanfacine lowers both systolic and diastolic blood pressure by activating the central nervous system α2A norepinephrine autoreceptors, which results in reduced peripheral sympathetic outflow and thus a reduction in peripheral sympathetic tone [1, 2]. |
| Name | N-(diaminomethylidene)-2-(2,6-dichlorophenyl)acetamide |
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| Synonym | More Synonyms |
| Description | Guanfacine is a selective α2A receptor agonist.Target: α2A ReceptorGuanfacine is a sympatholytic. It is a selective α2A receptor agonist. These receptors are concentrated heavily in the prefrontal cortex and the locus coeruleus, with the potential to improve attention resulting from interaction with receptors in the former. Guanfacine lowers both systolic and diastolic blood pressure by activating the central nervous system α2A norepinephrine autoreceptors, which results in reduced peripheral sympathetic outflow and thus a reduction in peripheral sympathetic tone [1, 2]. |
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| Related Catalog | |
| References |
| Density | 1.5±0.1 g/cm3 |
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| Boiling Point | 424.9ºC at 760 mmHg |
| Melting Point | 227-230?C |
| Molecular Formula | C9H9Cl2N3O |
| Molecular Weight | 246.093 |
| Flash Point | 210.8ºC |
| Exact Mass | 245.012268 |
| PSA | 78.97000 |
| LogP | 1.12 |
| Vapour Pressure | 2E-07mmHg at 25°C |
| Index of Refraction | 1.635 |
| Storage condition | Refrigerator |
| HS Code | 2925290090 |
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Guanfacine CAS#:29110-47-2 |
| Literature: Dodd, Dharmpal S.; Zhao, Yufen Tetrahedron Letters, 2001 , vol. 42, # 7 p. 1259 - 1262 |
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Guanfacine CAS#:29110-47-2 |
| Literature: Bream; Lauener; Picard; Scholtysik; White Arzneimittel-Forschung/Drug Research, 1975 , vol. 25, # 10 p. 1477 - 1482 |
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Guanfacine CAS#:29110-47-2 |
| Literature: Bream; Lauener; Picard; Scholtysik; White Arzneimittel-Forschung/Drug Research, 1975 , vol. 25, # 10 p. 1477 - 1482 |
| HS Code | 2925290090 |
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| Summary | 2925290090 other imines and their derivatives; salts thereof。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0% |
| Intuniv |
| Guanfacine |
| Guanfacina [INN-Spanish] |
| [(2,6-Dichlorophenyl)acetyl]guanidine |
| Guanfacine [INN:BAN] |
| Benzeneacetamide, N-(aminoiminomethyl)-2,6-dichloro- |
| N-amidino-2-(2,6-dichlorophenyl)acetamide |
| N-Carbamimidoyl-2-(2,6-dichlorophenyl)acetamide |
| Estulic |
| Lon798 |
| Guanfacina |
| N-(aminoiminomethyl)-2,6-dichlorobenzeneacetamide |
| Guanfacinum |
| Guanfacinum [INN-Latin] |
| BS 100-141 |
| Tenex |