66521-38-8

66521-38-8 structure

Name: Melatonin D5
Chemical Name: Melatonin-d4
CAS Number: 66521-38-8
Molecular Formula: C₁₃H₁₂D₄N₂O₂
Molecular Weight: 236.30300
Catalog: Signaling Pathways Autophagy Autophagy
Create Date: 2018-09-16 09:18:30
Modify Date: 2026-07-15 15:15:21
Melatonin D5 is deuterium labeled Melatonin. Melatonin is a hormone made by the pineal gland that can activates melatonin receptor. Antioxidative and anti-inflammatory properties[1][2][3]. Melatonin is a selective ATF-6 inhibitor and induces human hepatoma cell apoptosis through COX-2 downregulation[4].

Name	Melatonin-d4
Synonyms	MELATONIN-D4 N-ACETYL-5-METHOXYTRYPTAMINE-ALPHA,ALPHA,BETA,BETA-D4 N-Acetyl-5-methoxytryptamine-a,a-,-d4 N-[1,1,2,2-tetradeuterio-2-(5-methoxy-1H-indol-3-yl)ethyl]acetamide N-[1,1,2,2-Tetradeuterio-2-(5-methoxy-3-indolyl)ethyl]acetamide [2H4]-Melatonin ([α,α,β,β-2H4]-N-Acetyl-5-methoxytryptamine) D4-Melatonin (α,α,β,β-D4-N-Acetyl-5-methoxytryptamine) 2H4]-Melatonin ([α,α,β,β-2H4]-N-Acetyl-5-methoxytryptamine) N-(2-(5-Methoxy-1H-indol-3-yl)ethyl-1,1,2,2-d4)acetamide N-Acetyl-5-methoxytryptamine-α,α,β,β-d4 2H4]-Melatonin N-Acetyl-5-methoxytryptamine-a,a-b,b-d N-Acetyl-5-methoxytryptamine-α,α,β,beta-D4 N-Acetyl-5-methoxytryptamine-ααββ-[d4] N-[2-(5-methoxy-1H-indol-3-yl)(1,1,2,H)ethyl]acetamide Melatonine D4 N-Acetyl-5-methoxytryptamine D5 N-[2-(5-Methoxy-1H-indol-3-yl)ethyl]acetaMide-d4

Description	Melatonin D5 is deuterium labeled Melatonin. Melatonin is a hormone made by the pineal gland that can activates melatonin receptor. Antioxidative and anti-inflammatory properties[1][2][3]. Melatonin is a selective ATF-6 inhibitor and induces human hepatoma cell apoptosis through COX-2 downregulation[4].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Neuronal Signaling >> Melatonin Receptor Signaling Pathways >> Autophagy >> Autophagy Signaling Pathways >> GPCR/G Protein >> Melatonin Receptor Research Areas >> Inflammation/Immunology Signaling Pathways >> Autophagy >> Mitophagy Research Areas >> Neurological Disease
References	[1]. Kilic U, et al. Particular phosphorylation of PI3K/Akt on Thr308 via PDK-1 and PTEN mediates melatonin's neuroprotective activity after focal cerebral ischemia in mice. Redox Biol. 2017 Apr 5;12:657-665 [2]. Hu C, et al. Neuroprotective effect of melatonin on soluble Aβ1-42-induced cortical neurodegeneration via Reelin-Dab1 signaling pathway. Neurol Res. 2017 Apr 7:1-1 [3]. Rahim I, et al. Melatonin administration to wild-type mice and non-treated NLRP3 mutant mice share similar inhibition of the inflammatory response during sepsis. J Pineal Res. 2017 Mar 31 [4]. Bu LJ, et al. Melatonin, a novel selective ATF-6 inhibitor, induces human hepatoma cell apoptosis through COX-2 downregulation. World J Gastroenterol. 2017 Feb 14;23(6):986-998.