66521-38-8

66521-38-8 structure

Name: Melatonin D5
Chemical Name: Melatonin-d4
CAS Number: 66521-38-8
Molecular Formula: C₁₃H₁₂D₄N₂O₂
Molecular Weight: 236.30300
Catalog: Signaling Pathways Autophagy Autophagy
Create Date: 2018-09-16 09:18:30
Modify Date: 2025-08-28 09:41:53
Melatonin D5 is deuterium labeled Melatonin. Melatonin is a hormone made by the pineal gland that can activates melatonin receptor. Antioxidative and anti-inflammatory properties[1][2][3]. Melatonin is a selective ATF-6 inhibitor and induces human hepatoma cell apoptosis through COX-2 downregulation[4].

Name	Melatonin-d4
Synonyms	N-[1,1,2,2-tetradeuterio-2-(5-methoxy-1H-indol-3-yl)ethyl]acetamide

Description	Melatonin D5 is deuterium labeled Melatonin. Melatonin is a hormone made by the pineal gland that can activates melatonin receptor. Antioxidative and anti-inflammatory properties[1][2][3]. Melatonin is a selective ATF-6 inhibitor and induces human hepatoma cell apoptosis through COX-2 downregulation[4].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Neuronal Signaling >> Melatonin Receptor Signaling Pathways >> Autophagy >> Autophagy Signaling Pathways >> GPCR/G Protein >> Melatonin Receptor Research Areas >> Inflammation/Immunology Signaling Pathways >> Autophagy >> Mitophagy Research Areas >> Neurological Disease
References	[1]. Kilic U, et al. Particular phosphorylation of PI3K/Akt on Thr308 via PDK-1 and PTEN mediates melatonin's neuroprotective activity after focal cerebral ischemia in mice. Redox Biol. 2017 Apr 5;12:657-665 [2]. Hu C, et al. Neuroprotective effect of melatonin on soluble Aβ1-42-induced cortical neurodegeneration via Reelin-Dab1 signaling pathway. Neurol Res. 2017 Apr 7:1-1 [3]. Rahim I, et al. Melatonin administration to wild-type mice and non-treated NLRP3 mutant mice share similar inhibition of the inflammatory response during sepsis. J Pineal Res. 2017 Mar 31 [4]. Bu LJ, et al. Melatonin, a novel selective ATF-6 inhibitor, induces human hepatoma cell apoptosis through COX-2 downregulation. World J Gastroenterol. 2017 Feb 14;23(6):986-998.