67034-83-7

67034-83-7 structure

Name: DHEA-16,16-d2
Chemical Name: dehydroepiandrosterone-16,16-d2
CAS Number: 67034-83-7
Molecular Formula: C₁₉H₂₆D₂O₂
Molecular Weight: 290.43700
Create Date: 2016-02-27 12:49:35
Modify Date: 2024-01-03 16:34:01
DHEA-16,16-d2 is the deuterium labeled DHEA. DHEA (Prasterone) is one of the most abundant steroid hormones. DHEA (Prasterone) mediates its action via multiple signaling pathways involving specific membrane receptors and via transformation into androgen and estrogen derivatives (e.g., androgens, estrogens, 7α and 7β DHEA, and 7α and 7β epiandrosterone derivatives) acting through their specific receptors.

Name	dehydroepiandrosterone-16,16-d2

Description	DHEA-16,16-d2 is the deuterium labeled DHEA. DHEA (Prasterone) is one of the most abundant steroid hormones. DHEA (Prasterone) mediates its action via multiple signaling pathways involving specific membrane receptors and via transformation into androgen and estrogen derivatives (e.g., androgens, estrogens, 7α and 7β DHEA, and 7α and 7β epiandrosterone derivatives) acting through their specific receptors.
Related Catalog	Research Areas >> Cancer Research Areas >> Endocrinology Signaling Pathways >> Others >> Androgen Receptor
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Anagnostopoulou V, et al. Differential effects of dehydroepiandrosterone and testosterone in prostate and colon cancer cell apoptosis: the role of nerve growth factor (NGF) receptors. Endocrinology. 2013 Jul;154(7):2446-56. [3]. McNelis JC, et al. Dehydroepiandrosterone exerts anti-glucocorticoid action on human preadipocyte proliferation, differentiation and glucose uptake. Am J Physiol Endocrinol Metab. 2013 Nov 1;305(9):E1134-44. [4]. Catalina F, et al. Decrease of core body temperature in mice by dehydroepiandrosterone. Exp Biol Med (Maywood). 2002 Jun;227(6):382-8.

Molecular Formula	C₁₉H₂₆D₂O₂
Molecular Weight	290.43700
Exact Mass	290.22100
PSA	37.30000
LogP	3.87920

67034-83-7	352431-52-8
3188-46-3	362049-52-3
79037-35-7	89685-22-3
85235-22-9	56588-58-0
1232-73-1	136790-76-6
1158522-08-7	940364-43-2
134104-43-1	131615-57-1
6906-52-1	930439-75-1
1018584-77-4	1375289-11-4
849349-65-1	127437-46-1