Shanghai Nianxing Industrial Co., Ltd
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Product Name: Rauwolscine
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: methyl (16beta,17alpha,20alpha)-17-hydroxyyohimban-16-carboxylate
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131-03-3

131-03-3 structure

131-03-3 structure

Name: Rauwolscine
Chemical Name: rauwolscine
CAS Number: 131-03-3
Molecular Formula: C₂₁H₂₆N₂O₃
Molecular Weight: 354.443
Catalog: Natural product Alkaloid
Create Date: 2018-08-17 09:43:31
Modify Date: 2025-08-21 20:14:23
Rauwolscine is a selective α2-adrenoceptor antagonist that inhibits tumor growth and induces apoptosis[1].

Name	rauwolscine
Synonyms	isoyohimbine 17a-Hydroxy-20a-yohimban-16b-carboxylic Acid Methyl Ester KEOXIFENE Corynanthidine a-Yohimbine α-Yohimbine EINECS 205-006-9 20α-Yohimban-16β-carboxylic acid, 17α-hydroxy-, methyl ester (8CI) Rauwolscine RALOXIFENE HCL KEOXIFENE HYDROCHLORIDE Yohimban-16-carboxylic acid, 17-hydroxy-, methyl ester, (16β,17α,20α)- Methyl (16β,17α,20α)-17-hydroxyyohimban-16-carboxylate

Description	Rauwolscine is a selective α2-adrenoceptor antagonist that inhibits tumor growth and induces apoptosis[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor
In Vivo	Rauwolscine (0.5 mg/kg, daily) 通过增强细胞凋亡和减少细胞增殖来减少 Balb/c 雌性小鼠的肿瘤生长[1]。 Rauwolscine (i.v., 2.24 mg/kg) 能明显释放大鼠的舔食冲突反应，类似于α受体激动剂 clonidine (0.022 mg/kg) 和benzodiazepine diazepam (0.5 mg/kg)[2]。
References	[1]. A Bruzzone, et al. Alpha2-adrenoceptor action on cell proliferation and mammary tumour growth in mice. Br J Pharmacol. 2008 Oct;155(4):494-504. [2]. S La Marca, et al. The alpha-2 antagonists idazoxan and rauwolscine but not yohimbine or piperoxan are anxiolytic in the Vogel lick-shock conflict paradigm following intravenous administration. Life Sci. 1994;54(10):PL179-84.

Density	1.3±0.1 g/cm3
Boiling Point	543.0±50.0 °C at 760 mmHg
Melting Point	270-280ºC
Molecular Formula	C₂₁H₂₆N₂O₃
Molecular Weight	354.443
Flash Point	282.2±30.1 °C
Exact Mass	354.194336
PSA	65.56000
LogP	2.20
Vapour Pressure	0.0±1.5 mmHg at 25°C
Index of Refraction	1.661

CHEMICAL IDENTIFICATION

RTECS NUMBER :: ZG1005000

CHEMICAL NAME :: 20-alpha-Yohimban-16-beta-carboxylic acid, 17-alpha-hydroxy-, methyl ester

CAS REGISTRY NUMBER :: 131-03-3

LAST UPDATED :: 198708

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C21-H26-N2-O3

MOLECULAR WEIGHT :: 354.49

WISWESSER LINE NOTATION :: T F6 D5 C666 EM ON&&TTTJ TQ UVO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 50 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Behavioral - changes in motor activity (specific assay)

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 134,447,1961

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85IXA4 "Structure et Activite Pharmacodyanmique des Medicaments du Systeme Nerveux Vegetatif," Bovet, D., and F. Bovet-Nitti, New York, S. Karger, 1948 Volume(issue)/page/year: -,317,1948

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 80 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Behavioral - changes in motor activity (specific assay)

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 134,447,1961

Hazard Codes	Xi
Risk Phrases	23/24/25
Safety Phrases	22-36/37/39-45
RIDADR	UN 1544 6.1/PG 2
Packaging Group	II
Hazard Class	6.1(a)

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