112501-42-5

112501-42-5 structure

Name: 1-Hydroxy-2-methoxydibenzo[cd,f]indol-4(5H)-one
Chemical Name: Piperolactam A
CAS Number: 112501-42-5
Molecular Formula: C₁₆H₁₁NO₃
Molecular Weight: 265.26
Catalog: Natural product Alkaloid
Create Date: 2017-07-13 18:47:23
Modify Date: 2024-01-20 19:56:24
Piperolactam A is a natural product that can be isolated from root of Piper betle. Piperolactam A exhibits promising leishmanicidal action against wild type and drug resistant strains of Leishmania donovani[1].

Name	Piperolactam A
Synonyms	aristolactam FI piperolactam-A 1-Hydroxy-2-methoxydibenzo[cd,f]indol-4(5H)-one 10-amino-4-hydroxy-3-methoxyphenanthrene-1-carboxylic acid lactam Dibenz[cd,f]indol-4(5H)-one, 1-hydroxy-2-methoxy- piperlactam A

Description	Piperolactam A is a natural product that can be isolated from root of Piper betle. Piperolactam A exhibits promising leishmanicidal action against wild type and drug resistant strains of Leishmania donovani[1].
Related Catalog	Research Areas >> Infection
Target	Leishmania
In Vitro	Piperolactam A 对杜氏利什曼原虫野生型、耐药和野外分离的无菌无鞭毛体细胞系具有抑制活性，IC50 值为 60 ± 9.6 μM (野生型)，分别为 121 ± 18 μM (抗 SSG)、109 ± 15 μM (抗 PMM) 和 87 ± 12 μM (野外分离株)[1]。
References	[1]. Bhattacharya P, et al. In Vitro susceptibilities of wild and drug resistant Leishmania donovani amastigotes to piperolactam A loaded hydroxypropyl-β-cyclodextrin nanoparticles. Acta Trop. 2016 Jun;158:97-106.

Hazard Codes	Xi

53948-09-7

~64%

112501-42-5

Literature: KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY Patent: WO2009/51417 A2, 2009 ; Location in patent: Page/Page column 18-19 ;