Name | chrysosplenetin |
---|---|
Synonyms |
Chrysosplenetin
4H-1-Benzopyran-4-one, 5-hydroxy-2-(4-hydroxy-3-methoxyphenyl)-3,6,7-trimethoxy- 5,3'-Dipropyl-biphenyl-2,4'-diol chrysoplenitin 4',5-dihydroxy-3,6,7,3'-tetramethoxyflavone 3,6,7,3'-tetra-methylquercetagetin 5-Hydroxy-2-(4-hydroxy-3-methoxyphenyl)-3,6,7-trimethoxy-4H-chromen-4-one Tetrahydrohonokiol Chrysosplenetin B Tetrahydrohoenokiol chrysosplenol B Quercetagetin 3,6,7,3'-tetramethyl ether 5-Hydroxy-2-(4-hydroxy-3-methoxyphenyl)-3,6,7-trimethoxy-4H-chrom en-4-one |
Description | Chrysosplenetin is one of the polymethoxylated flavonoids in Artemisia annua L. (Compositae) and other several Chinese herbs. Chrysosplenetin inhibits P-gp activity and reverses the up-regulated P-gp and MDR1 levels induced by artemisinin (ART). Chrysosplenetin significantly augments the rat plasma level and anti-malarial efficacy of ART, partially due to the uncompetitive inhibition effect of Chrysosplenetin on rat CYP3A[1]. |
---|---|
Related Catalog | |
Target |
CYP3A |
References |
Density | 1.4±0.1 g/cm3 |
---|---|
Boiling Point | 615.8±55.0 °C at 760 mmHg |
Molecular Formula | C19H18O8 |
Molecular Weight | 374.341 |
Flash Point | 222.7±25.0 °C |
Exact Mass | 374.100159 |
PSA | 107.59000 |
LogP | 2.26 |
Vapour Pressure | 0.0±1.8 mmHg at 25°C |
Index of Refraction | 1.640 |
Storage condition | 2-8℃ |
Hazard Codes | Xi |
---|
~% 603-56-5 |
Literature: Brunet, Gunter; Ibrahim, Ragai K. Phytochemistry (Elsevier), 1980 , vol. 19, p. 741 - 746 |
Precursor 1 | |
---|---|
DownStream 0 |