54135-60-3
54135-60-3 structure
- Name: M 50054
- Chemical Name: 2-[(2,6-dioxocyclohexyl)methyl]cyclohexane-1,3-dione
- CAS Number: 54135-60-3
- Molecular Formula: C13H16O4
- Molecular Weight: 236.26400
- Catalog: Signaling Pathways Apoptosis Apoptosis
- Create Date: 2017-07-09 23:20:12
- Modify Date: 2024-01-05 11:16:50
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M50054 is a potent inhibitor of apoptosis. M50054 inhibits Etoposide-induced caspase-3 activation of U937 cells with an IC50 of 79 μg/mL. M50054 does not directly inhibit the enzymatic activity of caspase-3. M50054 can be used for the research anti-Fas-antibody-induced hepatitis and chemotherapy-induced alopecia[1].
| Name | 2-[(2,6-dioxocyclohexyl)methyl]cyclohexane-1,3-dione |
|---|---|
| Synonyms |
2,2'-methylenedicyclohexane-1,3-dione
2,2'-methanediyl-bis-cyclohexane-1,3-dione 2,2'-methylenebis(1,3-cyclohexanedione) 2,2'-Methandiyl-bis-cyclohexan-1,3-dion Bis-(2.6-dioxo-cyclohexyl)-methan Apoptosis Inhibitor 2,2'-methylenebis(cyclohexane-1,3-dione) |
| Description | M50054 is a potent inhibitor of apoptosis. M50054 inhibits Etoposide-induced caspase-3 activation of U937 cells with an IC50 of 79 μg/mL. M50054 does not directly inhibit the enzymatic activity of caspase-3. M50054 can be used for the research anti-Fas-antibody-induced hepatitis and chemotherapy-induced alopecia[1]. |
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| Related Catalog | |
| In Vitro | M50054 inhibits the caspase-3 activation by Etoposide in a dose-dependent manner. The IC50 value of M50054 against Etoposide-induced caspase-3 activation of U937 cells is 79 μg/mL. However, M50054 does not directly inhibit the enzymatic activity of caspase-3 at all concentrations up to 1000 μg/mL[1]. M50054 (1-300 μg/mL) inhibits soluble human Fas ligand-induced cell death of human Fas-expressing WC8 cells in a dose-dependent manner, and the IC50 of 67 μg/mL[1]. M50054 (30-300 μg/mL) inhibits the death of U937 cells induced by etoposide (10 μg/mL) in a dose-dependent manner, and the IC50 value of M50054 against Etoposide-induced cell death of U937 cells is 130 μg/mL. The IC50 value of M50054 against etoposide-induced DNA fragmentation of U937 cells was 54 μg/mL[1]. Cell Proliferation Assay[1] Cell Line: Human Fas-expressing WC8 cells Concentration: 1, 3, 10, 30, 100, 300 μg/mL Incubation Time: Pre-incubated for 30 min Result: Inhibited soluble human Fas ligand-induced cell death of human Fas-expressing WC8 cells in a dose-dependent manner, and the IC50 of 67 μg/mL. |
| In Vivo | M50054 (10-300 mg/kg; oral administration 30 min before anti-Fas antibody injection) inhibits the elevation of alanine aminotransferase and aspartate aminotransferase in a dose-dependent manner[1]. M50054 (topical treatment; given daily beginning on day 5 after birth and ending on day 14) significantly improves alopecia (hair loss) symptoms[1]. Animal Model: Female BALB/c mice[1] Dosage: 10, 30, 100 or 300 mg/kg Administration: Orally administered in a volume of 10 mL/kg Result: Inhibited the elevation of alanine aminotransferase and aspartate aminotransferase in a dose-dependent manner. Significantly improved these parameters at doses of 100 mg/kg and 300 mg/kg. Animal Model: Five-day-old SD rats[1] Dosage: Administration: Topically applied to the head and back of 5-day-old rats once daily for 10 days Result: Alopecia scores significantly decreased throughout the entire observation period compared with the control group. |
| References |
| Density | 1.227 g/cm3 |
|---|---|
| Boiling Point | 461.2ºC at 760 mmHg |
| Molecular Formula | C13H16O4 |
| Molecular Weight | 236.26400 |
| Flash Point | 199ºC |
| Exact Mass | 236.10500 |
| PSA | 68.28000 |
| LogP | 1.25310 |
| Index of Refraction | 1.52 |
| HS Code | 2914299000 |
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|
~97%
54135-60-3 |
| Literature: Yu, Jian-Jun; Wang, Li-Min; Liu, Jin-Qian; Guo, Feng-Lou; Liu, Ying; Jiao, Ning Green Chemistry, 2010 , vol. 12, # 2 p. 216 - 219 |
|
~%
54135-60-3 |
| Literature: Hellmann et al. Justus Liebigs Annalen der Chemie, 1959 , vol. 626, p. 35,45 |
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~%
54135-60-3 |
| Literature: Vorlaender; Kalkow Chemische Berichte, 1897 , vol. 30, p. 1802 Justus Liebigs Annalen der Chemie, 1899 , vol. 309, p. 359 |
| Precursor 4 | |
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| DownStream 3 | |
| HS Code | 2914299000 |
|---|---|
| Summary | 2914299000. other cyclanic, cyclenic or cyclotherpenic ketones without other oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:5.5%. General tariff:30.0% |