123852-08-4

123852-08-4 structure

Name: NH-bis(m-PEG4)
Chemical Name: 2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]-N-[2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethyl]ethanamine
CAS Number: 123852-08-4
Molecular Formula: C₁₈H₃₉NO₈
Molecular Weight: 397.50400
Catalog: Signaling Pathways PROTAC PROTAC Linker
Create Date: 2017-11-02 07:46:21
Modify Date: 2024-01-31 18:26:40
NH-bis(m-PEG4) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name	2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]-N-[2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethyl]ethanamine
Synonyms	N,N-bis(tetraethyleneglycol-monomethylether)amine N,N-bis(tetraoxyethylenemonomethyl ether)amine 2,5,8,11-Tetraoxatridecan-13-amine,N-3,6,9,12-tetraoxatridec-1-yl bis-[2-[2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxy]-ethyl]-amine

Description	NH-bis(m-PEG4) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

133531-78-9

~94%

123852-08-4

112-35-6

123852-08-4

Literature: Selve; Ravey; Stebe; El Moudjahid; Moumni; Delpuech Tetrahedron, 1991 , vol. 47, # 3 p. 411 - 428

62921-74-8

123852-08-4

Literature: Selve; Ravey; Stebe; El Moudjahid; Moumni; Delpuech Tetrahedron, 1991 , vol. 47, # 3 p. 411 - 428

Precursor 2
112-35-6 62921-74-8
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