NH-bis(m-PEG4)

Modify Date: 2024-01-31 18:26:40

Use of NH-bis(m-PEG4)

NH-bis(m-PEG4) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name	2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]-N-[2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethyl]ethanamine
Synonym	More Synonyms

Description	NH-bis(m-PEG4) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

N/A

CAS#:133531-78-9

~94%

NH-bis(m-PEG4)

CAS#:123852-08-4

Literature: Selve, Claude; Moumni, El Mostafa; Delpuech, Jean-Jacques Journal of the Chemical Society, Chemical Communications, 1987 , # 19 p. 1437 - 1438

m-PEG3-OH

CAS#:112-35-6

NH-bis(m-PEG4)

CAS#:123852-08-4

Literature: Selve; Ravey; Stebe; El Moudjahid; Moumni; Delpuech Tetrahedron, 1991 , vol. 47, # 3 p. 411 - 428

m-PEG3-Tos

CAS#:62921-74-8

NH-bis(m-PEG4)

CAS#:123852-08-4

Literature: Selve; Ravey; Stebe; El Moudjahid; Moumni; Delpuech Tetrahedron, 1991 , vol. 47, # 3 p. 411 - 428

Precursor 2
CAS#:112-35-6 m-PEG3-OH CAS#:62921-74-8 m-PEG3-Tos
DownStream 0

N,N-bis(tetraethyleneglycol-monomethylether)amine

N,N-bis(tetraoxyethylenemonomethyl ether)amine

2,5,8,11-Tetraoxatridecan-13-amine,N-3,6,9,12-tetraoxatridec-1-yl

bis-[2-[2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxy]-ethyl]-amine

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