144779-91-9

144779-91-9 structure

Name: (2S,3S)-3-[N-(Quinoxaline-2-carbonyl)-L-asparaginyl]amino-2-hydroxy-4- phenylbutanoyl-L-proline, tert-butylamide
Chemical Name: (2S)-N-[(2S,3S)-4-[(2S)-2-(tert-butylcarbamoyl)pyrrolidin-1-yl]-3-hydroxy-4-oxo-1-phenylbutan-2-yl]-2-(quinoxaline-2-carbonylamino)butanediamide
CAS Number: 144779-91-9
Molecular Formula: C₃₂H₃₉N₇O₆
Molecular Weight: 617.69500
Catalog: Signaling Pathways Metabolic Enzyme/Protease HIV Protease
Create Date: 2016-09-05 02:23:36
Modify Date: 2024-01-02 16:09:03
R-87366 is a water-soluble human immunodeficiency virus (HIV) protease inhibitor. R-87366 has potent inhibitory for HIV protease with a Ki value of 11 nM. R-87366 can be used for the research of anti-human immunodeficiency virus (HIV)[1].

Name	(2S)-N-[(2S,3S)-4-[(2S)-2-(tert-butylcarbamoyl)pyrrolidin-1-yl]-3-hydroxy-4-oxo-1-phenylbutan-2-yl]-2-(quinoxaline-2-carbonylamino)butanediamide
Synonyms	AHPBA analog

Description	R-87366 is a water-soluble human immunodeficiency virus (HIV) protease inhibitor. R-87366 has potent inhibitory for HIV protease with a Ki value of 11 nM. R-87366 can be used for the research of anti-human immunodeficiency virus (HIV)[1].
Related Catalog	Research Areas >> Inflammation/Immunology Signaling Pathways >> Metabolic Enzyme/Protease >> HIV Protease
Target	Ki: 11 nM (HIV protease)[1]. IC90: 0.5 μM (HIV-1IIIB acutely infected cells)[1]
In Vitro	R-87366 对人类免疫缺陷病毒蛋白酶具有强效抑制作用，Ki 值为 11 nM[1]。 R-87366 对 HIV-1IIIB 急性感染细胞具有活性，IC90 值为 0.5 μM[1]。 R-87366 具有中等水溶性[1]。 R-87366 (0.25 μM; 0.5 μM) 对慢性感染的 Molt-4/HIV-1IIIB 细胞也有活性，并抑制 p55 蛋白水解加工成 p17[1]。
References	[1]. T Komai, et al. In vitro and ex vivo anti-human immunodeficiency virus (HIV) activities of a new water-soluble HIV protease inhibitor, R-87366, containing (2S,3S)-3-amino-2-hydroxy-4-phenylbutanoic acid. Biol Pharm Bull. 1997 Feb;20(2):175-80.