Name | muramyl dipeptide |
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Synonyms |
2-Acetamido-2-deoxy-3-O-(D-2-propionyl-L-alanyl-D-isoglutamine)-D-glucopyranose
AC-MURAMYL-ALA-D-GLN Adjuvant Peptide,Muramyl dipeptide N-AC-MURAMYL-ALA-D-GLU-NH2 L-18-MDP MFCD00077638 AC-MURAMYL-ALA-D-GLU-NH2 ADJUVANT PEPTIDE MDP AC-MURAMYL-ALA-D-ISOGLN-OH N-ACETYLMURAMYL-L-ALANYL-D-ISOGLUTAMINE Nod2 ligand muramyl dipeptide N2-[N-(N-Acetylmuramoyl)-L-alanyl]-D-a-glutamine EINECS 258-696-9 (4R)-4-{[(2S)-2-{[(2R)-2-{[(3R,4R,5S,6R)-3-Acetamido-2,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-4-yl]oxy}propanoyl]amino}propanoyl]amino}-5-amino-5-oxopentanoic acid |
Description | Muramyl dipeptide (MDP) is a synthetic immunoreactive peptide, consisting of N-acetyl muramic acid attached to a short amino acid chain of L-Ala-D-isoGln. Muramyl dipeptide is an inducer of bone formation through induction of Runx2. Muramyl dipeptide directly enhances osteoblast differentiation by up-regulating Runx2 gene expression through MAPK pathways. Muramyl dipeptide indirectly attenuates osteoclast differentiation through a decreased RANKL/OPG ratio[1]. |
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Related Catalog | |
In Vitro | Muramyl dipeptide (0.1-10 µg/mL; 24 hours) increases protein expression of Runx2 in a dose-dependent manner[1]. Muramyl dipeptide (0.1-10 µg/mL; 6 hours) increases mRNA levels of Runx2 in a dose-dependent manner[1]. Western Blot Analysis[1] Cell Line: MC3T3-E1 cells Concentration: 0.1, 1, 10 µg/mL Incubation Time: 24 hours Result: Increased protein expression of Runx2 in a dose-dependent manner. RT-PCR[1] Cell Line: MC3T3-E1 cells Concentration: 0.1, 1, 10 µg/mL Incubation Time: 6 hours Result: Increases mRNA levels of Runx2 in a dose-dependent manner. |
In Vivo | Muramyl dipeptide (1.25 mg/kg; i.p.; twice) alleviates bone loss induced by osteoporosis[1]. Animal Model: RANKL-induced osteoporosis model (Five-week-old C57BL/6 mice)[1] Dosage: 1.25 mg/kg Administration: i.p.; twice (RANKL-induced osteoporosis for 3 weeks and euthanized at 4 weeks) Result: Significantly enhanced the trabecular bone volume (BV/TV) and trabecular number (Tb.N). |
References |
Density | 1.5±0.1 g/cm3 |
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Boiling Point | 1023.8±65.0 °C at 760 mmHg |
Molecular Formula | C19H32N4O11 |
Molecular Weight | 492.478 |
Flash Point | 572.9±34.3 °C |
Exact Mass | 492.206757 |
PSA | 246.84000 |
LogP | -2.97 |
Vapour Pressure | 0.0±0.6 mmHg at 25°C |
Index of Refraction | 1.578 |
Storage condition | −20°C |
Water Solubility | H2O: 10 mg/mL, clear, colorless |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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Safety Phrases | S22-S24/25 |
RIDADR | NONH for all modes of transport |
WGK Germany | 3 |
RTECS | MA2275260 |