Top Suppliers:I want be here
Related CAS#:
53678-77-6 56816-18-3
59331-38-3 60398-08-5
78113-36-7 66112-59-2
863918-60-9 45159-25-9
134938-79-7 25460-87-1
1044766-85-9 1044766-86-0
1044766-91-7 1044766-92-8
1044766-94-0 1044766-96-2
1160806-44-9 1044767-00-1
1222713-07-6 1044767-07-8

53678-77-6

53678-77-6 structure
53678-77-6 structure
  • Name: Ac-muramyl-Ala-D-Glu-NH2
  • Chemical Name: muramyl dipeptide
  • CAS Number: 53678-77-6
  • Molecular Formula: C19H32N4O11
  • Molecular Weight: 492.478
  • Catalog: Signaling Pathways MAPK/ERK Pathway ERK
  • Create Date: 2018-06-10 12:13:09
  • Modify Date: 2025-08-28 10:59:20
  • Muramyl dipeptide (MDP) is a synthetic immunoreactive peptide, consisting of N-acetyl muramic acid attached to a short amino acid chain of L-Ala-D-isoGln. Muramyl dipeptide is an inducer of bone formation through induction of Runx2. Muramyl dipeptide directly enhances osteoblast differentiation by up-regulating Runx2 gene expression through MAPK pathways. Muramyl dipeptide indirectly attenuates osteoclast differentiation through a decreased RANKL/OPG ratio[1].
Name muramyl dipeptide
Synonyms 2-Acetamido-2-deoxy-3-O-(D-2-propionyl-L-alanyl-D-isoglutamine)-D-glucopyranose
AC-MURAMYL-ALA-D-GLN
Adjuvant Peptide,Muramyl dipeptide
N-AC-MURAMYL-ALA-D-GLU-NH2
L-18-MDP
MFCD00077638
AC-MURAMYL-ALA-D-GLU-NH2
ADJUVANT PEPTIDE
MDP
AC-MURAMYL-ALA-D-ISOGLN-OH
N-ACETYLMURAMYL-L-ALANYL-D-ISOGLUTAMINE
Nod2 ligand muramyl dipeptide
N2-[N-(N-Acetylmuramoyl)-L-alanyl]-D-a-glutamine
EINECS 258-696-9
(4R)-4-{[(2S)-2-{[(2R)-2-{[(3R,4R,5S,6R)-3-Acetamido-2,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-4-yl]oxy}propanoyl]amino}propanoyl]amino}-5-amino-5-oxopentanoic acid
Description Muramyl dipeptide (MDP) is a synthetic immunoreactive peptide, consisting of N-acetyl muramic acid attached to a short amino acid chain of L-Ala-D-isoGln. Muramyl dipeptide is an inducer of bone formation through induction of Runx2. Muramyl dipeptide directly enhances osteoblast differentiation by up-regulating Runx2 gene expression through MAPK pathways. Muramyl dipeptide indirectly attenuates osteoclast differentiation through a decreased RANKL/OPG ratio[1].
Related Catalog
In Vitro Muramyl dipeptide (0.1-10 µg/mL; 24 hours) increases protein expression of Runx2 in a dose-dependent manner[1]. Muramyl dipeptide (0.1-10 µg/mL; 6 hours) increases mRNA levels of Runx2 in a dose-dependent manner[1]. Western Blot Analysis[1] Cell Line: MC3T3-E1 cells Concentration: 0.1, 1, 10 µg/mL Incubation Time: 24 hours Result: Increased protein expression of Runx2 in a dose-dependent manner. RT-PCR[1] Cell Line: MC3T3-E1 cells Concentration: 0.1, 1, 10 µg/mL Incubation Time: 6 hours Result: Increases mRNA levels of Runx2 in a dose-dependent manner.
In Vivo Muramyl dipeptide (1.25 mg/kg; i.p.; twice) alleviates bone loss induced by osteoporosis[1]. Animal Model: RANKL-induced osteoporosis model (Five-week-old C57BL/6 mice)[1] Dosage: 1.25 mg/kg Administration: i.p.; twice (RANKL-induced osteoporosis for 3 weeks and euthanized at 4 weeks) Result: Significantly enhanced the trabecular bone volume (BV/TV) and trabecular number (Tb.N).
References

[1]. Park OJ, et al. Muramyl Dipeptide, a Shared Structural Motif of Peptidoglycans, Is a Novel Inducer of Bone Formation through Induction of Runx2. J Bone Miner Res. 2017 Jul;32(7):1455-1468.
Density 1.5±0.1 g/cm3
Boiling Point 1023.8±65.0 °C at 760 mmHg
Molecular Formula C19H32N4O11
Molecular Weight 492.478
Flash Point 572.9±34.3 °C
Exact Mass 492.206757
PSA 246.84000
LogP -2.97
Vapour Pressure 0.0±0.6 mmHg at 25°C
Index of Refraction 1.578
Storage condition −20°C
Water Solubility H2O: 10 mg/mL, clear, colorless

CHEMICAL IDENTIFICATION

RTECS NUMBER :
MA2275260
CHEMICAL NAME :
D-alpha-Glutamine, N(sup 2)-(N-(N-acetylmuramoyl)-L-alanyl)-
CAS REGISTRY NUMBER :
53678-77-6
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C19-H32-N4-O11
MOLECULAR WEIGHT :
492.55

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intratesticular
DOSE :
800 ug/kg
SEX/DURATION :
male 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)
REFERENCE :
IJMRAQ Indian Journal of Medical Research. (Indian Council of Medical Research, Ansari Nagar, New Delhi 110 029, India) V.1- 1913- Volume(issue)/page/year: 74,251,1981
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Safety Phrases S22-S24/25
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS MA2275260
The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.

Chemsrc provides CAS#:53678-77-6 MSDS, density, melting point, boiling point, structure, formula, molecular weight, synthetic route, etc.
title: CAS No. 53678-77-6 | Chemsrc address: https://m.chemsrc.com/en/baike/540238.html

Home | MSDS/SDS Database Search | Journals | Product Classification | Biologically Active Compounds | Selling Leads | About Us | Disclaimer

Copyright © 2024 ChemSrc All Rights Reserved