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  • DC Chemicals Limited
  • China
  • Product Name: MST312
  • Price: $450.0/100mg $900.0/250mg $1800.0/1g $220.0/10ml
  • Purity: 98.0%
  • Stocking Period: 3 Day
  • Contact: Tony Cao

368449-04-1

368449-04-1 structure
368449-04-1 structure
  • Name: MST312
  • Chemical Name: N-[3-[(2,3-dihydroxybenzoyl)amino]phenyl]-2,3-dihydroxybenzamide
  • CAS Number: 368449-04-1
  • Molecular Formula: C20H16N2O6
  • Molecular Weight: 380.35100
  • Catalog: Signaling Pathways Cell Cycle/DNA Damage Telomerase
  • Create Date: 2016-03-24 01:46:37
  • Modify Date: 2024-01-09 11:28:18
  • MST-312 is a telomerase inhibitor. MST-312 is a chemically modified derivative of green tea epigallocatechin gallate (EGCG). MST-312 can be used for the research of cancer, such as multiple myeloma (MM)[1].

Name N-[3-[(2,3-dihydroxybenzoyl)amino]phenyl]-2,3-dihydroxybenzamide
Synonyms telomerase inhibitor IX
IN1063
N,N'-1,3-Phenylenebis-[2,3-dihydroxy-benzamide]
N,N'-bis(2,3-dihydroxybenzoyl)-1,3-phenylenediamine
N,N-1,3-phenylenebis-(2,3-dihydroxybenzamide)
MST-312
1,3-bis(2,3-dihydroxybenzamido)benzene
Benzamide,N,N'-1,3-phenylenebis[2,3-dihydroxy
MST312
Description MST-312 is a telomerase inhibitor. MST-312 is a chemically modified derivative of green tea epigallocatechin gallate (EGCG). MST-312 can be used for the research of cancer, such as multiple myeloma (MM)[1].
Related Catalog
Target

telomeras[1]

In Vitro MST-312 (2~8 μM; 0~72 hours; U-266 cells) reduces cellular viability in a dose dependent and time-dependent manner[1]. MST-312 (2~8 μM; 48 hours; U-266 cells) induces cell apoptosis in a dose-dependent manner[1]. MST-312 (2 μM; 48 hours; U-266 cells) up-regulates the pro-apoptotic gene Bax and down-regulates the anti-apoptotic gene Bcl-2 and suppresses the expression of c-Myc and hTERT genes[1]. Cell Viability Assay[1] Cell Line: U-266 cells Concentration: 2~8 μM Incubation Time: 0~72 hours Result: The viability of U-266 cells was substantially decreased in a dose dependent and time-dependent manner, in response to exposure to MST-312. Apoptosis Analysis[1] Cell Line: U-266 cells Concentration: 2~8 μM Incubation Time: 48 hours Result: Induced cell apoptosis in a dose-dependent manner. RT-PCR[1] Cell Line: U-266 cells Concentration: 2 μM Incubation Time: 48 hours Result: Up-regulated the pro-apoptotic gene Bax and down-regulated the anti-apoptotic gene Bcl-2 and suppressed the expression of c-Myc and hTERT genes.
References

[1]. Ameri Z, et al. Telomerase inhibitor MST-312 induces apoptosis of multiple myeloma cells and down-regulation of anti-apoptotic, proliferative and inflammatory genes. Life Sci. 2019;228:66-71.

Molecular Formula C20H16N2O6
Molecular Weight 380.35100
Exact Mass 380.10100
PSA 146.10000
LogP 3.78160
Storage condition 2-8°C
Symbol GHS09
GHS09
Signal Word Warning
Hazard Statements H400
Precautionary Statements P273
RIDADR UN 3077 9 / PGIII
Precursor  2

DownStream  0