368449-04-1
368449-04-1 structure
- Name: MST312
- Chemical Name: N-[3-[(2,3-dihydroxybenzoyl)amino]phenyl]-2,3-dihydroxybenzamide
- CAS Number: 368449-04-1
- Molecular Formula: C20H16N2O6
- Molecular Weight: 380.35100
- Catalog: Signaling Pathways Cell Cycle/DNA Damage Telomerase
- Create Date: 2016-03-24 01:46:37
- Modify Date: 2025-08-25 13:42:37
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MST-312 is a telomerase inhibitor. MST-312 is a chemically modified derivative of green tea epigallocatechin gallate (EGCG). MST-312 can be used for the research of cancer, such as multiple myeloma (MM)[1].
| Name | N-[3-[(2,3-dihydroxybenzoyl)amino]phenyl]-2,3-dihydroxybenzamide |
|---|---|
| Synonyms |
telomerase inhibitor IX
IN1063 N,N'-1,3-Phenylenebis-[2,3-dihydroxy-benzamide] N,N'-bis(2,3-dihydroxybenzoyl)-1,3-phenylenediamine N,N-1,3-phenylenebis-(2,3-dihydroxybenzamide) MST-312 1,3-bis(2,3-dihydroxybenzamido)benzene Benzamide,N,N'-1,3-phenylenebis[2,3-dihydroxy MST312 |
| Description | MST-312 is a telomerase inhibitor. MST-312 is a chemically modified derivative of green tea epigallocatechin gallate (EGCG). MST-312 can be used for the research of cancer, such as multiple myeloma (MM)[1]. |
|---|---|
| Related Catalog | |
| Target |
telomeras[1] |
| In Vitro | MST-312 (2~8 μM; 0~72 hours; U-266 cells) reduces cellular viability in a dose dependent and time-dependent manner[1]. MST-312 (2~8 μM; 48 hours; U-266 cells) induces cell apoptosis in a dose-dependent manner[1]. MST-312 (2 μM; 48 hours; U-266 cells) up-regulates the pro-apoptotic gene Bax and down-regulates the anti-apoptotic gene Bcl-2 and suppresses the expression of c-Myc and hTERT genes[1]. Cell Viability Assay[1] Cell Line: U-266 cells Concentration: 2~8 μM Incubation Time: 0~72 hours Result: The viability of U-266 cells was substantially decreased in a dose dependent and time-dependent manner, in response to exposure to MST-312. Apoptosis Analysis[1] Cell Line: U-266 cells Concentration: 2~8 μM Incubation Time: 48 hours Result: Induced cell apoptosis in a dose-dependent manner. RT-PCR[1] Cell Line: U-266 cells Concentration: 2 μM Incubation Time: 48 hours Result: Up-regulated the pro-apoptotic gene Bax and down-regulated the anti-apoptotic gene Bcl-2 and suppressed the expression of c-Myc and hTERT genes. |
| References |
| Molecular Formula | C20H16N2O6 |
|---|---|
| Molecular Weight | 380.35100 |
| Exact Mass | 380.10100 |
| PSA | 146.10000 |
| LogP | 3.78160 |
| Storage condition | 2-8°C |
| Symbol |
GHS09 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H400 |
| Precautionary Statements | P273 |
| RIDADR | UN 3077 9 / PGIII |
