41743-74-2

41743-74-2 structure

Name: toralactone
Chemical Name: toralactone
CAS Number: 41743-74-2
Molecular Formula: C₁₅H₁₂O₅
Molecular Weight: 272.25300
Catalog: Signaling Pathways NF-κB Keap1-Nrf2
Create Date: 2017-08-22 17:48:21
Modify Date: 2024-01-15 20:30:38
Toralactone, isolated from Cassia obtusifolia, mediates hepatoprotection via an Nrf2-dependent anti-oxidative mechanism[1].

Name	toralactone
Synonyms	Toralactone 9,10-dihydroxy-7-methoxy-3-methylbenzo[g]isochromen-1-one 9,10-Dihydroxy-7-methoxy-3-methyl-1H-naphtho(2,3-c)pyran-1-one torolactone

Description	Toralactone, isolated from Cassia obtusifolia, mediates hepatoprotection via an Nrf2-dependent anti-oxidative mechanism[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> NF-κB >> Keap1-Nrf2
In Vitro	Toralactone sensitize resistant MCF-7adr cell line to paclitaxel via inhibiting P-glycoprotein efflux activity[2].
References	[1]. YongtaekSeo, et al. Toralactone glycoside in Cassia obtusifolia mediates hepatoprotection via an Nrf2-dependent anti-oxidative mechanism. Food Research International. Volume 97, July 2017, Pages 340-346. [2]. Salwa D. Alqahtani, et al. Abstract 1205: Rubrofusarin and toralactone sensitize resistant MCF-7adr cell line to paclitaxel via inhibiting P-glycoprotein efflux activity. AACR Annual Meeting 2017; April 1-5, 2017; Washington, DC.

HS Code	2932999099

71602-63-6

~85%

41743-74-2

Literature: Zhang, Zhaojun; Yu, Biao Journal of Organic Chemistry, 2003 , vol. 68, # 16 p. 6309 - 6313

119170-52-4

41743-74-2

Literature: Kitanaka, Susumu; Takido, Michio Chemical & Pharmaceutical Bulletin, 1988 , vol. 36, # 10 p. 3980 - 3984

3686-57-5

41743-74-2

Literature: Zhang, Zhaojun; Yu, Biao Journal of Organic Chemistry, 2003 , vol. 68, # 16 p. 6309 - 6313

Precursor 2
71602-63-6 3686-57-5
DownStream 0

HS Code	2932999099
Summary	2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%