toralactone

Modify Date: 2024-01-15 20:30:38

toralactone Structure
toralactone structure
Common Name toralactone
CAS Number 41743-74-2 Molecular Weight 272.25300
Density 1.432g/cm3 Boiling Point 480.2ºC at 760mmHg
Molecular Formula C15H12O5 Melting Point N/A
MSDS N/A Flash Point 184.8ºC

 Use of toralactone


Toralactone, isolated from Cassia obtusifolia, mediates hepatoprotection via an Nrf2-dependent anti-oxidative mechanism[1].

 Names

Name toralactone
Synonym More Synonyms

 toralactone Biological Activity

Description Toralactone, isolated from Cassia obtusifolia, mediates hepatoprotection via an Nrf2-dependent anti-oxidative mechanism[1].
Related Catalog
In Vitro Toralactone sensitize resistant MCF-7adr cell line to paclitaxel via inhibiting P-glycoprotein efflux activity[2].
References

[1]. YongtaekSeo, et al. Toralactone glycoside in Cassia obtusifolia mediates hepatoprotection via an Nrf2-dependent anti-oxidative mechanism. Food Research International. Volume 97, July 2017, Pages 340-346.

[2]. Salwa D. Alqahtani, et al. Abstract 1205: Rubrofusarin and toralactone sensitize resistant MCF-7adr cell line to paclitaxel via inhibiting P-glycoprotein efflux activity. AACR Annual Meeting 2017; April 1-5, 2017; Washington, DC.

 Chemical & Physical Properties

Density 1.432g/cm3
Boiling Point 480.2ºC at 760mmHg
Molecular Formula C15H12O5
Molecular Weight 272.25300
Flash Point 184.8ºC
Exact Mass 272.06800
PSA 79.90000
LogP 2.67440
Index of Refraction 1.691
Storage condition 2-8℃

 Safety Information

HS Code 2932999099

 Synthetic Route

~85%

toralactone Structure

toralactone

CAS#:41743-74-2

Literature: Zhang, Zhaojun; Yu, Biao Journal of Organic Chemistry, 2003 , vol. 68, # 16 p. 6309 - 6313

~%

toralactone Structure

toralactone

CAS#:41743-74-2

Literature: Kitanaka, Susumu; Takido, Michio Chemical & Pharmaceutical Bulletin, 1988 , vol. 36, # 10 p. 3980 - 3984

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toralactone Structure

toralactone

CAS#:41743-74-2

Literature: Zhang, Zhaojun; Yu, Biao Journal of Organic Chemistry, 2003 , vol. 68, # 16 p. 6309 - 6313

 Precursor & DownStream

Precursor  2

DownStream  0

 Customs

HS Code 2932999099
Summary 2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Synonyms

Toralactone
9,10-dihydroxy-7-methoxy-3-methylbenzo[g]isochromen-1-one
9,10-Dihydroxy-7-methoxy-3-methyl-1H-naphtho(2,3-c)pyran-1-one
torolactone