10378-06-0

10378-06-0 structure

Name: (6R)-FR054
Chemical Name: methyl (3,4,6-tri-O-acetyl-1,2-dideoxy-α-D-glucopyrano)-[2,1-D]-Δ2-oxazolidine
CAS Number: 10378-06-0
Molecular Formula: C₁₄H₁₉NO₈
Molecular Weight: 329.30300
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2017-01-13 07:51:25
Modify Date: 2026-07-01 17:45:16
(6R)-FR054 is an active isomer of FR054. FR054 is an inhibitor of the HBP enzyme PGM3, with a remarkable anti-breast cancer effect. FR054induces endoplasmic reticulum (ER) stress and a ROS-dependent apoptosis[1].

Name	methyl (3,4,6-tri-O-acetyl-1,2-dideoxy-α-D-glucopyrano)-[2,1-D]-Δ2-oxazolidine
Synonyms	(3,7-5-(Acetoxymethyl)-2-Methyl-5,6,7,7A-Tetrahydro-3aH-Pyrano[3,2-D]Oxazole-6,7-Diyl Diacetate(WXC02555) (3,7-5-(Acetoxymethyl)-2-methyl-5,6,7,7a-tetrahydro-3aH-pyrano[3,2-d][1,3]oxazole-6,7-diyl diacetate FR054 inhibit,ERS,(6R)-FR054,Inhibitor,(6R) FR054,Apoptosis,TNBC,(6R)-FR-054,cancer,breast,(6R)FR054 2-methyl-(3,4,6-tri-O-acetyl-1,2-dideoxy-α-D-glucopyranosido)-[2,1-d]-2-oxazoline (6R)-FR054, 10 mM in DMSO WXC02555 (3,5R,6R,7R,7-5-(acetoxymethyl)-2-methyl-3a,6,7,7a-tetrahydro-5H-pyrano[3,2-d]oxazole-6,7-diyl diacetate 3',4',6'-Triacetate 2'-Deoxy-2-methyl-4,5-D-galactopyrano-Δ2-oxazoline 4',5'-dihydro-2'-methoxyoxazolo[5',4':1,2]-3,4,6-tri-O-acetyl-1,2-dideoxy-α-D-glucopyranoside 4',5'-dihydro-2'-methyloxazolo[5',4':1,2]-3,4,6-tri-O-acetyl-1,2-dideoxy-α-D-glucopyranose (3,7-5-(ACETOXYMETHYL)-2-METHYL-5,6,7,7A-TETRAHYDRO-3AH-PYRANO[3,2-D]OXAZOLE-6,7-DIYL DIACETATE 2-methyl-(3,4,6-tri-O-acetyl-1,2-dideoxy-α-D-glucopyrano)-[2',1':4,5]-2-oxazoline (3,5R,6R,7R,7-5-(Acetoxymethyl)-2-methyl-5,6,7,7a-tetrahydro-3aH-pyrano[3,2-d]oxazole-6,7-diyl diacetate 5H-Pyrano[3,2-d]oxazole-6,7-diol, 5-[(acetyloxy)methyl]-3a,6,7,7a-tetrahydro-2-methyl-, 6,7-diacetate, (3,5R,6R,7R,7) 2-methyl-(3,4,6-tri-O-acetyl-1,2-dideoxy-α-D-glucopyrano)-<2,1-d>-2-oxazoline 2-methyl-(3,4,6-tri-O-acetyl-1,2-dideoxy-α-D-glucopyranoso)-[2,1-d]-2-oxazoline

Description	(6R)-FR054 is an active isomer of FR054. FR054 is an inhibitor of the HBP enzyme PGM3, with a remarkable anti-breast cancer effect. FR054induces endoplasmic reticulum (ER) stress and a ROS-dependent apoptosis[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer
References	[1]. Francesca Ricciardiello, et al. Inhibition of the Hexosamine Biosynthetic Pathway by Targeting PGM3 Causes Breast Cancer Growth Arrest and Apoptosis. Cell Death Dis. 2018 Mar 7;9(3):377.