10378-06-0

• 常用中文名：(6R)-FR054
• 常用英文名：(6R)-FR054
• CAS号：10378-06-0
• 分子式：C₁₄H₁₉NO₈
• 分子量：329.30300
• 相关类别： 信号通路 细胞凋亡 细胞凋亡
• 发布时间：2017-01-13 07:51:25
• 更新时间：2026-07-01 17:45:16
• (6R)-FR054 是FR054 的一个活性异构体。FR054 是 HBP 酶 PGM3 的抑制剂,具有显著的抗乳腺癌活性。FR054 可诱导内质网应激和 ROS 依赖的细胞凋亡。

名称

• 中文名: (3aR,5R,6R,7R,7aR)-5-(乙酰氧基甲基)-2-甲基-5,6,7,7a-四氢-3aH-吡喃并[3,2-d]恶唑-6,7-二基二乙酸酯
• 英文名: methyl (3,4,6-tri-O-acetyl-1,2-dideoxy-α-D-glucopyrano)-[2,1-D]-Δ2-oxazolidine
• 中文别名: (3,5R,6R,7R,7-5-(乙酰氧基甲基)-2-甲基-5,6,7,7A-四氢-3AH-吡喃并[3,2-D]恶唑-6,7-二基二乙酸酯; 化合物(6R)-FR054,10 MM DMSO 溶液; 化合物(6R)-FR054; (3,7-5-(乙酰氧基甲基)-2-甲基-5,6,7,7A-四氢-3AH-吡喃并[3,2-D]噁唑-6,7-叉基二醋酸盐
• 英文别名: (3,7-5-(Acetoxymethyl)-2-Methyl-5,6,7,7A-Tetrahydro-3aH-Pyrano[3,2-D]Oxazole-6,7-Diyl Diacetate(WXC02555); (3,7-5-(Acetoxymethyl)-2-methyl-5,6,7,7a-tetrahydro-3aH-pyrano[3,2-d][1,3]oxazole-6,7-diyl diacetate; FR054; inhibit,ERS,(6R)-FR054,Inhibitor,(6R) FR054,Apoptosis,TNBC,(6R)-FR-054,cancer,breast,(6R)FR054; 2-methyl-(3,4,6-tri-O-acetyl-1,2-dideoxy-α-D-glucopyranosido)-[2,1-d]-2-oxazoline; (6R)-FR054, 10 mM in DMSO; WXC02555; (3,5R,6R,7R,7-5-(acetoxymethyl)-2-methyl-3a,6,7,7a-tetrahydro-5H-pyrano[3,2-d]oxazole-6,7-diyl diacetate; 3',4',6'-Triacetate 2'-Deoxy-2-methyl-4,5-D-galactopyrano-Δ2-oxazoline; 4',5'-dihydro-2'-methoxyoxazolo[5',4':1,2]-3,4,6-tri-O-acetyl-1,2-dideoxy-α-D-glucopyranoside; 4',5'-dihydro-2'-methyloxazolo[5',4':1,2]-3,4,6-tri-O-acetyl-1,2-dideoxy-α-D-glucopyranose; (3,7-5-(ACETOXYMETHYL)-2-METHYL-5,6,7,7A-TETRAHYDRO-3AH-PYRANO[3,2-D]OXAZOLE-6,7-DIYL DIACETATE; 2-methyl-(3,4,6-tri-O-acetyl-1,2-dideoxy-α-D-glucopyrano)-[2',1':4,5]-2-oxazoline; (3,5R,6R,7R,7-5-(Acetoxymethyl)-2-methyl-5,6,7,7a-tetrahydro-3aH-pyrano[3,2-d]oxazole-6,7-diyl diacetate; 5H-Pyrano[3,2-d]oxazole-6,7-diol, 5-[(acetyloxy)methyl]-3a,6,7,7a-tetrahydro-2-methyl-, 6,7-diacetate, (3,5R,6R,7R,7); 2-methyl-(3,4,6-tri-O-acetyl-1,2-dideoxy-α-D-glucopyrano)-<2,1-d>-2-oxazoline; 2-methyl-(3,4,6-tri-O-acetyl-1,2-dideoxy-α-D-glucopyranoso)-[2,1-d]-2-oxazoline

物化性质

• 分子式: C₁₄H₁₉NO₈
• 分子量: 329.30300
• 精确质量: 329.11100
• PSA: 109.72000
• 储存条件: 2-8°C

生物活性

• 描述: (6R)-FR054 是FR054 的一个活性异构体。FR054 是 HBP 酶 PGM3 的抑制剂,具有显著的抗乳腺癌活性。FR054 可诱导内质网应激和 ROS 依赖的细胞凋亡。
• 相关类别:
  信号通路 >> 细胞凋亡 >> 细胞凋亡
  研究领域 >> 癌症
• 参考文献:

  [1]. Francesca Ricciardiello, et al. Inhibition of the Hexosamine Biosynthetic Pathway by Targeting PGM3 Causes Breast Cancer Growth Arrest and Apoptosis. Cell Death Dis. 2018 Mar 7;9(3):377.

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