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98-92-0

98-92-0 structure
98-92-0 structure
  • Name: Nicotinamide
  • Chemical Name: 3-​Pyridinecarboxamide
  • CAS Number: 98-92-0
  • Molecular Formula: C6H6N2O
  • Molecular Weight: 122.125
  • Catalog: API Vitamins and minerals Vitamin B drugs
  • Create Date: 2018-02-05 08:00:00
  • Modify Date: 2026-06-30 10:07:41
  • Nicotinamide is a form of vitamin B3 that plays essential roles in cell physiology through facilitating NAD+ redox homeostasis and providing NAD+ as a substrate to a class of enzymes that catalyze non-redox reactions. Nicotinamide is an inhibitor of SIRT1.
Name 3-​Pyridinecarboxamide
Synonyms NICOTINAMIDE (NIACINAMIDE) 1000MG NEAT
Austrovit PP
Factor pp
Amidopyridine
amidp
component of Medriatric
NicotinaMide(VitaMin B3)VPP
Amnicotin
Vitamin PP, Pyridine-3-cboxamide
NIACINAMIDE,FCC
NicotinaMide, >=(HPLC)
3-Pyridinecarboxamide
Pyridine-3-carboxamide
Dipegyl
austrovitpp
Amide PP
Niacinamide, Nicotinic acid amide, Pyridine-3-cboxylic acid amide, Vitamin PP, VitaminB3
Benicot
NICOTINAMIDE extrapure
Niacinamide FCC
NIACINAMIDE ANUL
Witamina PP
Nicotinamide (Vitamin B3) solution
Dipigyl
NIACINAMIDE CELL CULTURE TESTED
Hansamid
NICOTINAMIDE TEST SUBSTANCE FOR ELEMENTA
MFCD00006395
NICOTINAMIDE, PH EUR
deloninamide
Inovitan PP
NIKOTINSAEUREAMID BP
Niacinamide/Nicotinamide
VitaMine PP
amidkyselinynikotinove
Vitamin B3
Nicotinamidum
Nicotinic acid amide
NicotinamideForBiochemistry
Vitamin- B3
nicotinamide (niacinamide)
Pyridin-3-cbonsαureamid
Nicotinamide(Niacinamide)Nicotinamide(Niacinamide)Bp
Pyridine-3-cboxyamide
VITAMIN B3(NIACINAMIDE)(P)
Nicotinamid
VITAMIN B3(NIACINAMIDE)(SH)
Amid kyseliny nikotinove
EINECS 202-713-4
Nicotinamide Bp
Niacinamide
beta-Pyridinecboxamide
NicotinamideB.P.,U.S.P
NicotinaMide 0
Niacinamide/nicotinamide 24,BP98,2000
NICOTINAMIDE
Vitamin PP 3-Pyridinecboxyamide
Delonin Amide
T6NJ CVZ
Amixicotyn
Vi-noctyl
Aminicotin
Nicotinamine
factorpp
Endobion
NICOTINAMIDE (VITAMIN B3)
Description Nicotinamide is a form of vitamin B3 that plays essential roles in cell physiology through facilitating NAD+ redox homeostasis and providing NAD+ as a substrate to a class of enzymes that catalyze non-redox reactions. Nicotinamide is an inhibitor of SIRT1.
Related Catalog
Target

PARP-1

Human Endogenous Metabolite

In Vitro Pretreatment with the poly (ADP-ribose) polymerase (PARP) inhibitor nicotinamide is able to prevent HCN2 cell death. When nicotinamide is added prior to t-BuOOH, it is able to prevent neuronal cell death and inhibit apoptosis. Nicotinamide-pretreated neurons have higher expression levels of inhibitors of apoptosis (IAP) genes[1]. Nicotinamide inhibits vasoconstriction by ET. Nicotinamide also alleviates oxidative stress, which exacerbates PE and FGR[3].
In Vivo Normal and streptozotocin-nicotinamide induced adult male diabetic rats receive quercetin (10, 25 and 50 mg/kg/bw) orally, and cause significant decrease in FBG and cardiac injury marker levels with increased in insulin levels[2]. Nicotinamide improves maternal hypertension, proteinuria, and glomerular endotheliosis in RUPP mice. Moreover, nicotinamide prolongs pregnancies, and improves survival and growth of the embryos in RUPP PE mice[3].
Animal Admin DM is induced via a single intraperitoneal (i.p) injection of nicotinamide (110 mg/kg/body weight) dissolved in normal saline 15 min prior to streptozotocin (STZ) (55 mg/kg/body weight) injection, which is dissolved in a freshly prepared 0.1mol/Lcitrate buffer (pH 4.5). These injections are given following an overnight fast. Control rats (n=6) are injected with the same amount of solvent. In order to prevent hypoglycemia in the first 24 h following STZ injection, rats are allowed to have free access to water with 5% dextrose (D5W). Three days after STZ-nicotinamide injection, rats with FBG levels greater than 7.0 mM are considered as diabetic.
References

[1]. Bhansali SG, et al. Nicotinamide prevents apoptosis in human cortical neuronal cells. Toxicol Mech Methods. 2006;16(4):173-80.

[2]. Roslan J, et al. Quercetin ameliorates oxidative stress, inflammation and apoptosis in the heart of streptozotocin-nicotinamide-induced adult male diabetic rats. Biomed Pharmacother. 2016 Dec 24;86:570-582

[3]. Fushima T, et al. Nicotinamide ameliorates a preeclampsia-like condition in mice with reduced uterine perfusion pressure. Am J Physiol Renal Physiol. 2016 Dec 7:ajprenal.00501.2016

[4]. Suzuki E, et al. Protective effect of nicotinamide against poly(ADP-ribose) polymerase-1-mediated astrocyte death depends on its transporter-mediated uptake. Life Sci. 2010 Apr 24;86(17-18):676-82.
Density 1.2±0.1 g/cm3
Boiling Point 257.7±32.0 °C at 760 mmHg
Melting Point 128-131 °C(lit.)
Molecular Formula C6H6N2O
Molecular Weight 122.125
Flash Point 109.7±25.1 °C
Exact Mass 122.048012
PSA 55.98000
LogP -0.24
Appearance powder | white
Vapour Pressure 0.0±0.6 mmHg at 25°C
Index of Refraction 1.590
Storage condition 0-6°C
Stability Stable. Incompatible with strong oxidizing agents.
Water Solubility 1000 g/L (20 ºC)

CHEMICAL IDENTIFICATION

RTECS NUMBER :
QS3675000
CHEMICAL NAME :
Nicotinamide
CAS REGISTRY NUMBER :
98-92-0
LAST UPDATED :
199701
DATA ITEMS CITED :
15
MOLECULAR FORMULA :
C6-H6-N2-O
MOLECULAR WEIGHT :
122.14
WISWESSER LINE NOTATION :
T6NJ CVZ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
3500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1680 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - other changes
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
2500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
2050 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Mammal - species unspecified
DOSE/DURATION :
2500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :
Sister chromatid exchange
TEST SYSTEM :
Rodent - hamster Ovary
DOSE/DURATION :
5 mmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 126,63,1984 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 1 mg/m3 JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M0321 No. of Facilities: 1142 (estimated) No. of Industries: 6 No. of Occupations: 15 No. of Employees: 17336 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M0321 No. of Facilities: 2791 (estimated) No. of Industries: 8 No. of Occupations: 34 No. of Employees: 64950 (estimated) No. of Female Employees: 44524 (estimated)
Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H315-H319-H335
Precautionary Statements P261-P305 + P351 + P338
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xi
Risk Phrases R36/37/38
Safety Phrases S26;S36
RIDADR NONH for all modes of transport
WGK Germany 1
RTECS QS3675000
HS Code 2933399090
HS Code 2933399090
Summary 2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
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