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4695-09-4

4695-09-4 structure
4695-09-4 structure
  • Name: Thiomandelic acid
  • Chemical Name: 2-phenyl-2-sulfanylacetic acid
  • CAS Number: 4695-09-4
  • Molecular Formula: C8H8O2S
  • Molecular Weight: 168.21300
  • Catalog: Signaling Pathways Anti-infection Bacterial
  • Create Date: 2017-12-06 02:57:25
  • Modify Date: 2024-01-21 15:10:25
  • Thiomandelic acid is a broad spectrum inhibitor of Zinc -lactamases[1].
Name 2-phenyl-2-sulfanylacetic acid
Synonyms Thiomandelic acid
rac-Thiomandelsaeure
phenylmercaptoacetic acid
Description Thiomandelic acid is a broad spectrum inhibitor of Zinc -lactamases[1].
Related Catalog
In Vitro Thiomandelic acid is found to be a reasonably potent (submicromolar) inhibitor for all of the MBLs tested, except for the subclass B2 enzyme from A. hydrophila (CphA)[1]. Thiomandelic Acid binds to both metal ions in metallo-β-lactamase and induces positive cooperativity in metal binding[2].
References

[1]. C Mollard, et al. Thiomandelic acid, a broad spectrum inhibitor of zinc beta-lactamases: kinetic and spectroscopic studies. J Biol Chem. 2001 Nov 30;276(48):45015-23.

[2]. Christian Damblon, et al. The inhibitor thiomandelic acid binds to both metal ions in metallo-beta-lactamase and induces positive cooperativity in metal binding. J Biol Chem. 2003 Aug 1;278(31):29240-51.
Molecular Formula C8H8O2S
Molecular Weight 168.21300
Exact Mass 168.02500
PSA 76.10000
LogP 1.74210
Hazard Codes Xi
41128-19-2 structure

41128-19-2

~88%

4695-09-4 structure

4695-09-4
Literature: THE UNIVERSITY OF EDINBURGH; WEBSTER, Scott, Peter; SECKL, Jonathan, Robert; WALKER, Brian, Robert; WARD, Peter; PALLIN, Thomas, David; DYKE, Hazel, Joan; PERRIOR, Trevor, Robert Patent: WO2010/146338 A1, 2010 ; Location in patent: Page/Page column 77 ; WO 2010/146338 A1
4870-65-9 structure

4870-65-9

~68%

4695-09-4 structure

4695-09-4
Literature: Kudelko, Agnieszka Tetrahedron, 2012 , vol. 68, # 18 p. 3616 - 3625
1762-68-1 structure

1762-68-1

~68%

4695-09-4 structure

4695-09-4
Literature: A. H. Robins Company, Inc. Patent: US5061720 A1, 1991 ; US 5061720 A
611-71-2 structure

611-71-2

~%

4695-09-4 structure

4695-09-4
Literature: Lu, Dongning; Nadas, Janos; Zhang, Guisheng; Johnson, Wesley; Zweier, Jay L.; Cardounel, Arturo J.; Villamena, Frederick A.; Wang, Peng George Journal of the American Chemical Society, 2007 , vol. 129, # 17 p. 5503 - 5514
4755-72-0 structure

4755-72-0

~%

4695-09-4 structure

4695-09-4
Literature: Parravano; Tommasi Gazzetta Chimica Italiana, 1909 , vol. 39 II, p. 62
56601-83-3 structure

56601-83-3

~%

4695-09-4 structure

4695-09-4
Literature: McIntosh, John M.; Siddiqui, Maqbool A. Canadian Journal of Chemistry, 1983 , vol. 61, p. 1872 - 1875
623-11-0 structure

623-11-0
4695-07-2 structure

4695-07-2

~%

611-73-4 structure

611-73-4
4695-09-4 structure

4695-09-4
Literature: Schoeberl; Berninger; Harren Chemische Berichte, 1934 , vol. 67, p. 1545,1550 Full Text Show Details Schoeberl; Eck Justus Liebigs Annalen der Chemie, 1936 , vol. 522, p. 97,107

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