Thiomandelic acid
Thiomandelic acid structure
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Common Name | Thiomandelic acid | ||
|---|---|---|---|---|
| CAS Number | 4695-09-4 | Molecular Weight | 168.21300 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C8H8O2S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Thiomandelic acidThiomandelic acid is a broad spectrum inhibitor of Zinc -lactamases[1]. |
| Name | 2-phenyl-2-sulfanylacetic acid |
|---|---|
| Synonym | More Synonyms |
| Description | Thiomandelic acid is a broad spectrum inhibitor of Zinc -lactamases[1]. |
|---|---|
| Related Catalog | |
| In Vitro | Thiomandelic acid is found to be a reasonably potent (submicromolar) inhibitor for all of the MBLs tested, except for the subclass B2 enzyme from A. hydrophila (CphA)[1]. Thiomandelic Acid binds to both metal ions in metallo-β-lactamase and induces positive cooperativity in metal binding[2]. |
| References |
| Molecular Formula | C8H8O2S |
|---|---|
| Molecular Weight | 168.21300 |
| Exact Mass | 168.02500 |
| PSA | 76.10000 |
| LogP | 1.74210 |
| Hazard Codes | Xi |
|---|
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~88%
Thiomandelic acid CAS#:4695-09-4 |
| Literature: THE UNIVERSITY OF EDINBURGH; WEBSTER, Scott, Peter; SECKL, Jonathan, Robert; WALKER, Brian, Robert; WARD, Peter; PALLIN, Thomas, David; DYKE, Hazel, Joan; PERRIOR, Trevor, Robert Patent: WO2010/146338 A1, 2010 ; Location in patent: Page/Page column 77 ; WO 2010/146338 A1 |
|
~68%
Thiomandelic acid CAS#:4695-09-4 |
| Literature: Kudelko, Agnieszka Tetrahedron, 2012 , vol. 68, # 18 p. 3616 - 3625 |
|
~68%
Thiomandelic acid CAS#:4695-09-4 |
| Literature: A. H. Robins Company, Inc. Patent: US5061720 A1, 1991 ; US 5061720 A |
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~%
Thiomandelic acid CAS#:4695-09-4 |
| Literature: Lu, Dongning; Nadas, Janos; Zhang, Guisheng; Johnson, Wesley; Zweier, Jay L.; Cardounel, Arturo J.; Villamena, Frederick A.; Wang, Peng George Journal of the American Chemical Society, 2007 , vol. 129, # 17 p. 5503 - 5514 |
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~%
Thiomandelic acid CAS#:4695-09-4 |
| Literature: Parravano; Tommasi Gazzetta Chimica Italiana, 1909 , vol. 39 II, p. 62 |
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~%
Thiomandelic acid CAS#:4695-09-4 |
| Literature: McIntosh, John M.; Siddiqui, Maqbool A. Canadian Journal of Chemistry, 1983 , vol. 61, p. 1872 - 1875 |
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~%
Thiomandelic acid CAS#:4695-09-4 |
| Literature: Schoeberl; Berninger; Harren Chemische Berichte, 1934 , vol. 67, p. 1545,1550 Full Text Show Details Schoeberl; Eck Justus Liebigs Annalen der Chemie, 1936 , vol. 522, p. 97,107 |
| Precursor 7 | |
|---|---|
| DownStream 2 | |
CAS#:13148-63-5![2,3-Dihydrobenzo[b]thiophene-2-one structure](https://image.chemsrc.com/caspic/442/496-31-1.png)
CAS#:496-31-1| Thiomandelic acid |
| rac-Thiomandelsaeure |
| phenylmercaptoacetic acid |