Top Suppliers:I want be here


  • DC Chemicals Limited
  • China
  • Product Name: BTB-1
  • Price: $300.0/100mg $600.0/250mg $1200.0/1g
  • Purity: 98.0%
  • Stocking Period: 3 Day
  • Contact: Tony Cao

86030-08-2

86030-08-2 structure
86030-08-2 structure
  • Name: BTB1
  • Chemical Name: 1-(benzenesulfonyl)-4-chloro-2-nitrobenzene
  • CAS Number: 86030-08-2
  • Molecular Formula: C12H8ClNO4S
  • Molecular Weight: 297.71400
  • Catalog: Signaling Pathways Cell Cycle/DNA Damage Microtubule/Tubulin
  • Create Date: 2018-04-20 08:00:00
  • Modify Date: 2024-01-11 16:06:04
  • BTB-1 is a potent, selective and reversible mitotic motor protein Kif18A inhibitor with an IC50 of 1.69 μM.

Name 1-(benzenesulfonyl)-4-chloro-2-nitrobenzene
Synonyms 4-Chloro-2-nitrodiphenylsulfone
4-Chlor-2-nitro-diphenylsulfon
4-Chloro-2-nitro-1-(phenylsulfonyl)benzene
(4-Chlor-2-nitro-phenyl)-phenyl-sulfon
4-chloro-2-nitrodiphenyl sulphone
4-chloro-2-nitrophenyl phenyl sulfone
BTB-1
Description BTB-1 is a potent, selective and reversible mitotic motor protein Kif18A inhibitor with an IC50 of 1.69 μM.
Related Catalog
Target

IC50: 1.69 μM (Kif18A)[1]

In Vitro BTB-1 blocks the motility of Kif18A in a reversible manner. BTB-1 inhibits Kif18A in an adenosine triphosphate (ATP)-competitive but microtubule-uncompetitive manner and slows down the progression of cells through mitosis. 100 μM BTB-1 does not significantly inhibit any of the other tested mitotic kinesins. BTB-1 competes with ATP for Kif18A binding only when the motor-protein is associated with its pseudosubstrate microtubules. HeLa cells treated with BTB-1 accumulate in mitosis in a dose-dependent manner[1]. BTB-1 shows cell toxicity with an EC50 values of 35.8 μM. HeLa cells treated with 50 μM BTB-1 reveals severe defects in spindle morphology and chromosome alignment. Treatment with high concentrations of BTB-1 does not result in elongated spindles[2].
Kinase Assay BTB-1 is prepared in DMSO. The activity of His-Kif18Amotor at increasing concentrations of ATP is monitored in the presence of 3 μM Mts and increasing concentrations of BTB-1 (0.21 μM, 0.42 μM, 0.85 μM, 1.7 μM) or DMSO as control[1].
References

[1]. Catarinella M, et al. BTB-1: a small molecule inhibitor of the mitotic motor protein Kif18A. Angew Chem Int Ed Engl. 2009;48(48):9072-6.

[2]. Braun J, et al. Synthesis and biological evaluation of optimized inhibitors of the mitotic kinesin Kif18A. ACS Chem Biol. 2015 Feb 20;10(2):554-60.

Density 1.476g/cm3
Boiling Point 471.2ºC at 760mmHg
Melting Point 115ºC
Molecular Formula C12H8ClNO4S
Molecular Weight 297.71400
Flash Point 238.8ºC
Exact Mass 296.98600
PSA 88.34000
LogP 4.68500
Index of Refraction 1.623
Storage condition 2-8℃
Risk Phrases 36/37/38
Safety Phrases S26-S36-S37-S39

~%

86030-08-2 structure

86030-08-2

Literature: Journal of the Chemical Society, , p. 1618,1621

~%

86030-08-2 structure

86030-08-2

Literature: Journal of the Chemical Society, , p. 1618,1621

~%

86030-08-2 structure

86030-08-2

Literature: Journal of the Chemical Society [Section] B: Physical Organic, , p. 260 - 266

~7%

86030-08-2 structure

86030-08-2

Literature: Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), , p. 105 - 108