2238-90-6
2238-90-6 structure
- Name: Psychosine
- Chemical Name: psychosine
- CAS Number: 2238-90-6
- Molecular Formula: C24H47NO7
- Molecular Weight: 461.63200
- Catalog: Biochemical Chinese herbal medicine ingredients
- Create Date: 2018-04-24 08:00:00
- Modify Date: 2024-01-02 16:30:06
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Psychosine (Galactosylsphingosine), a substrate of the galactocerebrosidase (GALC) enzyme, is a potential biomarker for Krabbe disease[1]. Psychosine is a highly cytotoxic lipid, capable of inducing cell death in a wide variety of cell types including, most relevantly to globoid cell leukodystrophy (GLD), oligodendrocytes. Psychosine causes cell death at least in part via apoptosis. Psychosine also is an inhibitor of PKC[1].
| Name | psychosine |
|---|---|
| Synonyms |
Galactosylsphingosine
D-galactosyl-ß1-1'-D-erythro-sphingosine 1-B-D-GALACTOSYLSPHINOGOSINE Psychosine from bovine brain PSYCHOSIN PSYCHOSINE D-GALACTOSYL-B1-1' SPHINGOSN LYSO-CERAMIDEGALACTOSIDE MFCD00057505 O-Galactosylsphingosine LYSO-CEREBROSIDE |
| Description | Psychosine (Galactosylsphingosine), a substrate of the galactocerebrosidase (GALC) enzyme, is a potential biomarker for Krabbe disease[1]. Psychosine is a highly cytotoxic lipid, capable of inducing cell death in a wide variety of cell types including, most relevantly to globoid cell leukodystrophy (GLD), oligodendrocytes. Psychosine causes cell death at least in part via apoptosis. Psychosine also is an inhibitor of PKC[1]. |
|---|---|
| Related Catalog | |
| Target |
PKC |
| In Vitro | Psychosine, is a substrate of the GALC enzyme that shows promise to aid in the diagnosis and follow-up of at-risk infants identified through newborn screening (NBS)[1]. Psychosine induces pleiotropic effects, including dysfunctions in several cellular pathways[2]. Cell Viability Assay[2] Cell Line: Oligodendrocyte cells, M03.13 Concentration: 10, 20, and 40 μM Incubation Time: 24 hours Result: Caused cell death at least in part via apoptosis. |
| References |
| Density | 1.14 g/cm3 |
|---|---|
| Boiling Point | 664.3ºC |
| Molecular Formula | C24H47NO7 |
| Molecular Weight | 461.63200 |
| Flash Point | 355.6ºC |
| Exact Mass | 461.33500 |
| PSA | 145.63000 |
| LogP | 2.44870 |
| Vapour Pressure | 1.77E-20mmHg at 25°C |
| Index of Refraction | 1.535 |
| Storage condition | −20°C |
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302-H312-H332 |
| Precautionary Statements | P280 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xn: Harmful; |
| Risk Phrases | R20/21/22 |
| Safety Phrases | 36 |
| RIDADR | NONH for all modes of transport |
| Precursor 0 | |
|---|---|
| DownStream 3 | |
