55-43-6

55-43-6 structure

Name: Dibenamine hydrochloride
Chemical Name: N-(2-Chloroethyl)dibenzylamine hydrochloride
CAS Number: 55-43-6
Molecular Formula: C₁₆H₁₉Cl₂N
Molecular Weight: 296.23500
Catalog: Organic raw materials Amino compound Acyclic monoamines, polyamines and their derivatives and salts
Create Date: 2018-12-31 20:20:56
Modify Date: 2024-01-12 13:29:07
Dibenamine hydrochloride is a competitive and irreversible adrenergic blocking agent and is known to modify the pharmacological effects of epinephrine. Dibenamine hydrochloride cause a significant increase in the rate of destruction of I-epinephrine in the mouse[1][2].

Name	N-(2-Chloroethyl)dibenzylamine hydrochloride
Synonyms	N,N-dibenzyl-2-chloroethanamine,hydrochloride MFCD00012518 EINECS 200-234-5

Description	Dibenamine hydrochloride is a competitive and irreversible adrenergic blocking agent and is known to modify the pharmacological effects of epinephrine. Dibenamine hydrochloride cause a significant increase in the rate of destruction of I-epinephrine in the mouse[1][2].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor Research Areas >> Metabolic Disease
Target	IC50: Adrenergic receptor[1]
In Vitro	Dibenamine (100 nM-10 μM) attenuates the degree of cocaine-induced increase in sensitivity to acetylcholine without any effect on acetylcholine-contraction in isolated vas deferens of guinea pig. Additionally, the degree of dibenamine-induced inhibition dependent on the concentration of dibenamine and inversely related to the concentration of cocaine[3].
In Vivo	Dibenamine hydrochloride (subcutaneous injection; 25 mg/kg; 48 and 24 hr before the administration of CCl4) decreases the CHCl3, levels at 2 and 6 hr by 30-50 percent, but did not appreciably affect the half-life of CHCl3, in the liver.Pretreatment with Dibenamine apparently slows the conversion of Ccl4 to CHCL3[1].
References	[1]. R W SCHAYER, et al. Effect of dibenamine (N-(2-chloroethyl) dibenzylamine) on the metabolism of radioactive epinephrine.J Biol Chem. 1953 May;202(1):39-43. [2]. H M Maling,et al. Nature of the protection against carbon tetrachloride-induced hepatotoxicity produced by pretreatment with dibenamine (N-(2-chloroethyl)dibenzylamine). Biochem Pharmacol. 1974 May 15;23(10):1479-91. [3]. K Araki, et al. Pharmacological studies on supersensitization. VII. Inhibitory effect of dibenamine on cocaine-induced supersensitivity of isolated vas deferens of guinea pig. J Pharmacobiodyn. 1982 Oct;5(10):789-95.

Density	1.107g/cm3
Boiling Point	320ºC at 760mmHg
Melting Point	190-193 °C(lit.)
Molecular Formula	C₁₆H₁₉Cl₂N
Molecular Weight	296.23500
Flash Point	147.3ºC
Exact Mass	295.08900
PSA	3.24000
LogP	4.72960

CHEMICAL IDENTIFICATION

RTECS NUMBER :: HQ6825000

CHEMICAL NAME :: Dibenzylamine, N-(2-chloroethyl)-, hydrochloride

CAS REGISTRY NUMBER :: 55-43-6

LAST UPDATED :: 199706

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C16-H18-Cl-N.Cl-H

MOLECULAR WEIGHT :: 296.26

WISWESSER LINE NOTATION :: G2N1R&1R &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 75 mg/kg

TOXIC EFFECTS :: Gastrointestinal - ulceration or bleeding from small intestine

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 89,167,1947

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 400 mg/kg

TOXIC EFFECTS :: Gastrointestinal - ulceration or bleeding from small intestine

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 89,167,1947

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 50 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory stimulation

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 89,167,1947

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 35 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory stimulation

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 89,167,1947

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi
Risk Phrases	36/37/38
Safety Phrases	S26-S37/39
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	HQ6825000
HS Code	2921499090

Precursor 0
DownStream 1
51-50-3

HS Code	2921499090
Summary	2921499090 other aromatic monoamines and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

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