Name | [2-(2,6-dimethylanilino)-2-oxoethyl]-triethylazanium,chloride |
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Synonyms |
Lidocaine N-ethyl chloride
lidocaine ethochloride QX 314 chloride |
Description | QX-314 chloride is a membrane-impermeable permanently charged sodium channel blocker[1]. |
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Related Catalog | |
Target |
sodium channel[1] |
In Vitro | QX-314 chloride exerts biphasic effects on transient receptor potential vanilloid subtype 1 channels (TRPV1) in vitro[2]. QX-314 chloride (1–60 mM) directly activates TRPV1 in a concentration-dependent manner[2]. QX-314 chloride (10 mM) inhibits calcium currents in hippocampal CA1 pyramidal neurons intracellular, and the low-threshold (T-type) Ca2+ currents are on average < 45% of control amplitude[2]. |
References |
Melting Point | 209-211 °C |
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Molecular Formula | C16H27ClN2O |
Molecular Weight | 298.85100 |
Exact Mass | 298.18100 |
PSA | 29.10000 |
LogP | 0.19540 |
Storage condition | 2-8°C |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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Safety Phrases | 22-24/25 |
RIDADR | NONH for all modes of transport |
HS Code | 2924299090 |
~% 5369-03-9 |
Literature: Loefgren; Fischer Svensk Kemisk Tidskrift, 1946 , vol. 58, p. 219,229 |
HS Code | 2924299090 |
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Summary | 2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |