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5369-03-9

5369-03-9 structure

5369-03-9 structure

Name: QX 314 chloride
Chemical Name: [2-(2,6-dimethylanilino)-2-oxoethyl]-triethylazanium,chloride
CAS Number: 5369-03-9
Molecular Formula: C₁₆H₂₇ClN₂O
Molecular Weight: 298.85100
Catalog: Signaling Pathways Membrane Transporter/Ion Channel Sodium Channel
Create Date: 2018-12-14 11:32:12
Modify Date: 2025-08-20 08:05:25
QX-314 chloride is a membrane-impermeable permanently charged sodium channel blocker[1].

Name	[2-(2,6-dimethylanilino)-2-oxoethyl]-triethylazanium,chloride
Synonyms	Lidocaine N-ethyl chloride lidocaine ethochloride QX 314 chloride

Description	QX-314 chloride is a membrane-impermeable permanently charged sodium channel blocker[1].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> Sodium Channel Research Areas >> Neurological Disease
Target	sodium channel[1]
In Vitro	QX-314 chloride exerts biphasic effects on transient receptor potential vanilloid subtype 1 channels (TRPV1) in vitro[2]. QX-314 chloride (1–60 mM) directly activates TRPV1 in a concentration-dependent manner[2]. QX-314 chloride (10 mM) inhibits calcium currents in hippocampal CA1 pyramidal neurons intracellular, and the low-threshold (T-type) Ca2+ currents are on average < 45% of control amplitude[2].
References	[1]. Rivera-Acevedo RE, et al. The quaternary lidocaine derivative, QX-314, exerts biphasic effects on transient receptor potential vanilloid subtype 1 channels in vitro. Anesthesiology. 2011 Jun;114(6):1425-34. [2]. Talbot MJ, et al. Intracellular QX-314 inhibits calcium currents in hippocampal CA1 pyramidal neurons. J Neurophysiol. 1996 Sep;76(3):2120-4.

Melting Point	209-211 °C
Molecular Formula	C₁₆H₂₇ClN₂O
Molecular Weight	298.85100
Exact Mass	298.18100
PSA	29.10000
LogP	0.19540
Storage condition	2-8°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :: BT0430000

CHEMICAL NAME :: Ammonium, triethyl((2,6-xylylcarbamoyl)methyl)-, chloride

CAS REGISTRY NUMBER :: 5369-03-9

LAST UPDATED :: 198806

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C16-H27-N2-O.Cl

MOLECULAR WEIGHT :: 298.90

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 25 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: APSXAS Acta Pharmaceutica Suecica. (Apotekarsocieteten-Farmacevtiska Foereningen, Box 1136, S-111, 81 Stockholm, Sweden) V.1- 1964- Volume(issue)/page/year: 2,213,1965

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Safety Phrases	22-24/25
RIDADR	NONH for all modes of transport
HS Code	2924299090

75-00-3 structure

75-00-3

137-58-6 structure

137-58-6

~%

5369-03-9 structure

5369-03-9

Literature: Loefgren; Fischer Svensk Kemisk Tidskrift, 1946 , vol. 58, p. 219,229

Precursor 2
75-00-3 137-58-6
DownStream 0

HS Code	2924299090
Summary	2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

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