QX 314 chloride
QX 314 chloride structure
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Common Name | QX 314 chloride | ||
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| CAS Number | 5369-03-9 | Molecular Weight | 298.85100 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C16H27ClN2O | Melting Point | 209-211 °C | |
| MSDS | Chinese USA | Flash Point | N/A | |
Use of QX 314 chlorideQX-314 chloride is a membrane-impermeable permanently charged sodium channel blocker[1]. |
| Name | [2-(2,6-dimethylanilino)-2-oxoethyl]-triethylazanium,chloride |
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| Synonym | More Synonyms |
| Description | QX-314 chloride is a membrane-impermeable permanently charged sodium channel blocker[1]. |
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| Related Catalog | |
| Target |
sodium channel[1] |
| In Vitro | QX-314 chloride exerts biphasic effects on transient receptor potential vanilloid subtype 1 channels (TRPV1) in vitro[2]. QX-314 chloride (1–60 mM) directly activates TRPV1 in a concentration-dependent manner[2]. QX-314 chloride (10 mM) inhibits calcium currents in hippocampal CA1 pyramidal neurons intracellular, and the low-threshold (T-type) Ca2+ currents are on average < 45% of control amplitude[2]. |
| References |
| Melting Point | 209-211 °C |
|---|---|
| Molecular Formula | C16H27ClN2O |
| Molecular Weight | 298.85100 |
| Exact Mass | 298.18100 |
| PSA | 29.10000 |
| LogP | 0.19540 |
| Storage condition | 2-8°C |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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| Safety Phrases | 22-24/25 |
| RIDADR | NONH for all modes of transport |
| HS Code | 2924299090 |
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~%
QX 314 chloride CAS#:5369-03-9 |
| Literature: Loefgren; Fischer Svensk Kemisk Tidskrift, 1946 , vol. 58, p. 219,229 |
| Precursor 2 | |
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| DownStream 0 | |
| HS Code | 2924299090 |
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| Summary | 2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
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Snx14 regulates neuronal excitability, promotes synaptic transmission, and is imprinted in the brain of mice. Huang HS, Yoon BJ, Brooks S, et al.
PLoS ONE 9(5) , e98383, (2014)
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BDNF-induced presynaptic facilitation of GABAergic transmission in the hippocampus of young adults is dependent of TrkB and adenosine A2A receptors.
Purinergic Signal. 12 , 283-94, (2016) Brain-derived neurotrophic factor (BDNF) and adenosine are widely recognized as neuromodulators of glutamatergic transmission in the adult brain. Most BDNF actions upon excitatory plasticity phenomena... |
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Role of P2X4 receptors in synaptic strengthening in mouse CA1 hippocampal neurons.
Eur. J. Neurosci. 34 , 213-20, (2011) P2X4 receptors are calcium-permeable cation channels gated by extracellular ATP. They are found close to subsynaptic sites on hippocampal CA1 neurons. We compared features of synaptic strengthening be... |
| Lidocaine N-ethyl chloride |
| lidocaine ethochloride |
| QX 314 chloride |