DC Chemicals Limited
China
Product Name: SB 204741
Price: ￥Inquiry/1g
Purity: 98.9%
Stocking Period: 1 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: (S)-(+)-2-CHLOROPROPAN-1-OL
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

152239-46-8

152239-46-8 structure

152239-46-8 structure

Name: SB 204741
Chemical Name: 1-(1-methylindol-5-yl)-3-(3-methyl-1,2-thiazol-5-yl)urea
CAS Number: 152239-46-8
Molecular Formula: C₁₄H₁₄N₄OS
Molecular Weight: 286.35200
Catalog: Signaling Pathways GPCR/G Protein 5-HT Receptor
Create Date: 2018-12-24 17:01:02
Modify Date: 2024-01-14 18:25:01
SB 204741 is a selective and high affinity 5-HT2B antagonist with a pKi value of 7.1[1].

Name	1-(1-methylindol-5-yl)-3-(3-methyl-1,2-thiazol-5-yl)urea
Synonyms	Tocris-1372 N-(1-Methyl-1H-5-indolyl)-N'-(3-methyl-5-isothiazolyl)urea Lopac-S-0693

Description	SB 204741 is a selective and high affinity 5-HT2B antagonist with a pKi value of 7.1[1].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor
Target	human 5-HT2B Receptor:7.1 (pKi)
In Vitro	The most selective 5-HT2B receptor ligand to be tested is SB 204741 with approximately 20 fold selectivity for the human 5-HT2B receptor as compared to the human 5-HT2C receptor[1].
In Vivo	SB-204741 (0.25~1.0 mg/kg; i.p.) induces myocardial remodeling and dose dependently improves hemodynamic and ventricular functions following isoproterenol-induced myocardial injury[1]. SB-204741 bolsters endogenous anti-oxidant enzymes activities, improves cardiac injury markers, NO level and lipid peroxidation level and attenuates TNFα level in isoproterenol-induced myocardial remodeling in rats. SB-204741 (0.5 and 1.0 mg/kg/day) pre-treatment for 28 days significantly amplifies NO level and GSH and SOD activities and attenuates TBARS level following isoproterenol-induced myocardial remodeling. SB-204741 inhibits inflammatory protein expression, upregulates autophagy and HSPs protein expressions in isoproterenol-induced myocardial remodeling in rats. SB-204741 improves myocardial architecture in isoproterenol-induced myocardial remodeling in rats[1]. Animal Model: Rats[1] Dosage: 0.25~1.0 mg/kg Administration: I.p. Result: Induced myocardial remodeling.
References	[1]. Bonhaus DW, et al. The pharmacology and distribution of human 5-hydroxytryptamine2B (5-HT2B) receptor gene products: comparison with 5-HT2A and 5-HT2C receptors. Br J Pharmacol. 1995;115(4):622-628. [2]. Bharti S, et al. 5-HT2B receptor blockade attenuates β-adrenergic receptor-stimulated myocardial remodeling in rats via inhibiting apoptosis: role of MAPKs and HSPs. Apoptosis. 2015;20(4):455-465.

Density	1.38g/cm3
Boiling Point	335.9ºC at 760 mmHg
Molecular Formula	C₁₄H₁₄N₄OS
Molecular Weight	286.35200
Flash Point	157ºC
Exact Mass	286.08900
PSA	87.19000
LogP	3.73320
Vapour Pressure	0.000116mmHg at 25°C
Index of Refraction	1.707
Storage condition	2-8°C

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
RIDADR	NONH for all modes of transport