Shanghai Nianxing Industrial Co., Ltd
China
Product Name: LY171883
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ShangHai DC Chemicals Co.,Ltd
China
Product Name: Tomelukast
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Purity: 98.9%
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DC Chemicals Limited
China
Product Name: Tomelukast
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: LY 171883
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88107-10-2

88107-10-2 structure

88107-10-2 structure

Name: LY 171883
Chemical Name: tomelukast
CAS Number: 88107-10-2
Molecular Formula: C₁₆H₂₂N₄O₃
Molecular Weight: 318.37
Catalog: Surfactant Anionic surfactant Other anionic surfactants
Create Date: 2018-02-07 08:00:00
Modify Date: 2024-01-01 23:50:26
Tomelukast (LY171883) is an orally active leukotriene D4 and E4 antagonist. Tomelukast can be used for the research of asthma[1].

Name	tomelukast
Synonyms	MFCD00211057 Ethanone, 1-[2-hydroxy-3-propyl-4-[4-(1H-tetrazol-5-yl)butoxy]phenyl]- Tomelukast 1-[2-hydroxy-3-propyl-4-[4-(2H-tetrazol-5-yl)butoxy]phenyl]ethanone 1-{2-Hydroxy-3-propyl-4-[4-(1H-tetrazol-5-yl)butoxy]phenyl}ethanone Tomelukastum

Description	Tomelukast (LY171883) is an orally active leukotriene D4 and E4 antagonist. Tomelukast can be used for the research of asthma[1].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Leukotriene Receptor Research Areas >> Inflammation/Immunology
Target	leukotriene D4, leukotriene E4[1]
References	[1]. Abraham WM, et al. The effect of an orally active leukotriene D4/E4 antagonist, LY171883, on antigen-induced airway responses in allergic sheep. Prostaglandins. 1986 Mar;31(3):457-67.

Density	1.2±0.1 g/cm3
Boiling Point	553.0±60.0 °C at 760 mmHg
Melting Point	117-119℃
Molecular Formula	C₁₆H₂₂N₄O₃
Molecular Weight	318.37
Flash Point	288.3±32.9 °C
Exact Mass	318.169189
PSA	100.99000
LogP	3.27
Vapour Pressure	0.0±1.5 mmHg at 25°C
Index of Refraction	1.574
Storage condition	Store at +4°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :: KM5780800

CHEMICAL NAME :: Ethanone, 1-(2-hydroxy-3-propyl-4-(4-(1H-tetrazol-5-yl)butoxy)p henyl)-

CAS REGISTRY NUMBER :: 88107-10-2

LAST UPDATED :: 199612

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C16-H22-N4-O3

MOLECULAR WEIGHT :: 318.42

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 650 mg/kg

TOXIC EFFECTS :: Liver - other changes

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Primate - monkey

DOSE/DURATION :: >500 mg/kg

TOXIC EFFECTS :: Gastrointestinal - hypermotility, diarrhea

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 18250 mg/kg/1Y-C

TOXIC EFFECTS :: Liver - changes in liver weight Kidney, Ureter, Bladder - changes in bladder weight Biochemical - Effect on specific coenzyme - NAD,NADP

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3010 mg/kg/2W-C

TOXIC EFFECTS :: Liver - changes in liver weight Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - catalases Biochemical - Metabolism (Intermediary) - lipids including transport

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Primate - monkey

DOSE/DURATION :: 63875 mg/kg/1Y-I

TOXIC EFFECTS :: Liver - changes in liver weight Kidney, Ureter, Bladder - changes in bladder weight Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other Enzymes

MUTATION DATA

TEST SYSTEM :: Rodent - rat

DOSE/DURATION :: 1260 mg/kg/1W (Continuous)

REFERENCE :: CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980- Volume(issue)/page/year: 12,1557,1991

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xn: Harmful;
Risk Phrases	R22
Safety Phrases	36
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	KM5780800

92518-07-5 structure

92518-07-5

~76%

88107-10-2 structure

88107-10-2

Literature: Bernstein; Vacek Synthesis, 1987 , # 12 p. 1133 - 1134

7440-44-0 structure

7440-44-0

92518-07-5 structure

92518-07-5

~%

88107-10-2 structure

88107-10-2

Literature: US4661505 A1, ;

Precursor 1
7440-44-0
DownStream 0