LY 171883

Modify Date: 2026-07-04 15:40:03

LY 171883 structure	Common Name	LY 171883
	CAS Number	88107-10-2	Molecular Weight	318.37
	Density	1.2±0.1 g/cm3	Boiling Point	553.0±60.0 °C at 760 mmHg
	Molecular Formula	C₁₆H₂₂N₄O₃	Melting Point	117-119℃
	MSDS	Chinese USA	Flash Point	288.3±32.9 °C
	Symbol	GHS07	Signal Word	Warning

Use of LY 171883

Tomelukast (LY171883) is an orally active leukotriene D4 and E4 antagonist. Tomelukast can be used for the research of asthma[1].

Name	tomelukast
Synonym	More Synonyms

Description	Tomelukast (LY171883) is an orally active leukotriene D4 and E4 antagonist. Tomelukast can be used for the research of asthma[1].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Leukotriene Receptor Research Areas >> Inflammation/Immunology
Target	leukotriene D4, leukotriene E4[1]
References	[1]. Abraham WM, et al. The effect of an orally active leukotriene D4/E4 antagonist, LY171883, on antigen-induced airway responses in allergic sheep. Prostaglandins. 1986 Mar;31(3):457-67.

Density	1.2±0.1 g/cm3
Boiling Point	553.0±60.0 °C at 760 mmHg
Melting Point	117-119℃
Molecular Formula	C₁₆H₂₂N₄O₃
Molecular Weight	318.37
Flash Point	288.3±32.9 °C
Exact Mass	318.169189
PSA	100.99000
LogP	3.27
Vapour Pressure	0.0±1.5 mmHg at 25°C
Index of Refraction	1.574
InChIKey	MWYHLEQJTQJHSS-UHFFFAOYSA-N
SMILES	CCCc1c(OCCCCc2nn[nH]n2)ccc(C(C)=O)c1O
Storage condition	Store at +4°C

LY 171883 MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: KM5780800

CHEMICAL NAME :: Ethanone, 1-(2-hydroxy-3-propyl-4-(4-(1H-tetrazol-5-yl)butoxy)p henyl)-

CAS REGISTRY NUMBER :: 88107-10-2

LAST UPDATED :: 199612

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C16-H22-N4-O3

MOLECULAR WEIGHT :: 318.42

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 650 mg/kg

TOXIC EFFECTS :: Liver - other changes

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Primate - monkey

DOSE/DURATION :: >500 mg/kg

TOXIC EFFECTS :: Gastrointestinal - hypermotility, diarrhea

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 18250 mg/kg/1Y-C

TOXIC EFFECTS :: Liver - changes in liver weight Kidney, Ureter, Bladder - changes in bladder weight Biochemical - Effect on specific coenzyme - NAD,NADP

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3010 mg/kg/2W-C

TOXIC EFFECTS :: Liver - changes in liver weight Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - catalases Biochemical - Metabolism (Intermediary) - lipids including transport

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Primate - monkey

DOSE/DURATION :: 63875 mg/kg/1Y-I

TOXIC EFFECTS :: Liver - changes in liver weight Kidney, Ureter, Bladder - changes in bladder weight Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other Enzymes

MUTATION DATA

TEST SYSTEM :: Rodent - rat

DOSE/DURATION :: 1260 mg/kg/1W (Continuous)

REFERENCE :: CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980- Volume(issue)/page/year: 12,1557,1991

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xn: Harmful;
Risk Phrases	R22
Safety Phrases	36
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	KM5780800

N/A

CAS#:92518-07-5

~76%

LY 171883

CAS#:88107-10-2

Learn More

Literature: Bernstein; Vacek Synthesis, 1987 , # 12 p. 1133 - 1134

Carbon

CAS#:7440-44-0

N/A

CAS#:92518-07-5

LY 171883

CAS#:88107-10-2

Learn More

Literature: US4661505 A1, ;

Precursor 1
CAS#:7440-44-0 Carbon
DownStream 0

Role of leukotrienes in N-(3,5-dichlorophenyl)succinimide (NDPS) and NDPS metabolite nephrotoxicity in male Fischer 344 rats.

Toxicology 300(1-2) , 92-9, (2012)

The agricultural fungicide N-(3,5-dichlorophenyl)succinimide (NDPS) can induce marked nephrotoxicity in rats following a single intraperitoneal (ip) administration of 0.4mmol/kg or greater. Although N...

Effect of leukotriene C4 exposure on ciliated cells of the nasal mucosa.

Prostaglandins 51(1) , 69-79, (1996)

To clarify the effects of leukotriene C4 (LTC4) on human ciliated epithelium, ciliary activity of the ethmoid sinus mucosa was measured photoelectrically in tissue culture. At concentrations ranging f...

Blood cell-vascular wall interactions and the production of coronary contracting sulfidopeptide leukotrienes in isolated, cell- perfused, rabbit heart.

Adv. Prostaglandin. Thromboxane. Leukot. Res. 23 , 385-7, (1995)

Name: Primary qHTS assay for inhibitors of alpha-synuclein gene (SNCA) expression
Source: NCGC
External Id: SNCA-p-activity-luciferase

Name: Fluorescence-based cell-based primary high throughput screening assay to identify ago...
Source: The Scripps Research Institute Molecular Screening Center
Target: muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id: CHRM1_AG_FLUO8_1536_1X%ACT PRUN

Name: Cytochrome P450 Family 1 Subfamily A Member 2 (CYP1A2) small molecule antagonists: lu...
Source: 824
External Id: CYP273

Name: Ability to inhibit the rat PMN (polymorphonuclear leukocyte) CO (cyclo-oxygenase) in ...
Source: ChEMBL
Target: Prostaglandin G/H synthase 1
External Id: CHEMBL821467

Name: Fluorescence-based cell-based primary high throughput screening assay to identify pos...
Source: The Scripps Research Institute Molecular Screening Center
Target: muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id: CHRM1_PAM_FLUO8_1536_1X%ACT PRUN

Name: qHTS Assay for Small Molecule Inhibitors of the Human hERG Channel Activity
Source: NCGC
External Id: HERG01

Name: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen
Source: NCGC
Target: N/A
External Id: SMAD3201

Name: uHTS identification of cystic fibrosis induced NFkb Inhibitors in a fluoresence assay
Source: Burnham Center for Chemical Genomics
Target: cystic fibrosis transmembrane conductance regulator [Homo sapiens]
External Id: SBCCG-A764-CF-PAF-Primary-Assay

Name: Fluorescence-based cell-based primary high throughput screening assay to identify ant...
Source: The Scripps Research Institute Molecular Screening Center
Target: muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id: CHRM1_ANT_FLUO8_1536_1X%INH PRUN

Name: qHTS for Inhibitors of TGF-b
Source: NCGC
Target: Smad3 [Homo sapiens]
External Id: SMAD3101

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MFCD00211057

Tomelukast

1-[2-hydroxy-3-propyl-4-[4-(2H-tetrazol-5-yl)butoxy]phenyl]ethanone

1-{2-Hydroxy-3-propyl-4-[4-(1H-tetrazol-5-yl)butoxy]phenyl}ethanone

Tomelukastum

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: LY171883
Price: Check
Purity: 98.0%
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: LY 171883
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
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Zhongshan Xingrui Chemical Co. , Ltd.
China
Product Name: LY 171883
Price: ￥Inquiry/25kg
Purity: 99.0%
Delivery: Inquiry
Contact: Wang Jie
Email: 3096638339@qq.com

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Use of LY 171883

Names

LY 171883 Biological Activity

Chemical & Physical Properties

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

Safety Information

Synthetic Route

Precursor & DownStream

Articles26

LY 171883Bioassay

Synonyms

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.