189224-48-4
189224-48-4 structure
- Name: KU14R
- Chemical Name: 2-(2-ethyl-3H-1-benzofuran-2-yl)-1H-imidazole
- CAS Number: 189224-48-4
- Molecular Formula: C13H14N2O
- Molecular Weight: 214.263
- Catalog: Biochemical Inhibitor Protein tyrosine kinase
- Create Date: 2016-07-22 20:21:44
- Modify Date: 2025-08-25 11:26:36
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KU14R is a new I(3)-R antagonist, which selectively blocks the insulin secretory response to imidazolines.IC50 Value:Target: Insulin ReceptorA new I(3)-R antagonist, KU14R (2 (2-ethyl 2,3-dihydro-2-benzofuranyl)-2-imidazole), which selectively blocks the insulin secretory response to imidazolines. KU14R partially attenuated responses to Imidazole-4-acetic acid-ribotide (IAA-RP). The effects of KU14R on stimulus secretion-coupling in normal mouse islets and beta cells was compared by measuring KATP channel activity, plasma membrane potential, cytosolic calcium concentration ([Ca2+]c) and dynamic insulin secretion. In the presence of 10 mmol/l but not of 5 mmol/l glucose, KU14R (30, 100 or 300 micromol/l) was ineffective. KATP channel was blocked by KU14R (IC50 31.9 micromol/l, Hill slope -1.5). KU14R does not act as an antagonist of either efaroxan or S22068 at an imidazoline site in vivo.
| Name | 2-(2-ethyl-3H-1-benzofuran-2-yl)-1H-imidazole |
|---|---|
| Synonyms |
cs-1007
1H-Imidazole, 2-(2-ethyl-2,3-dihydro-2-benzofuranyl)- hms3267m22 ku14r 2-(2-Ethyl-2,3-dihydro-1-benzofuran-2-yl)-1H-imidazole |
| Description | KU14R is a new I(3)-R antagonist, which selectively blocks the insulin secretory response to imidazolines.IC50 Value:Target: Insulin ReceptorA new I(3)-R antagonist, KU14R (2 (2-ethyl 2,3-dihydro-2-benzofuranyl)-2-imidazole), which selectively blocks the insulin secretory response to imidazolines. KU14R partially attenuated responses to Imidazole-4-acetic acid-ribotide (IAA-RP). The effects of KU14R on stimulus secretion-coupling in normal mouse islets and beta cells was compared by measuring KATP channel activity, plasma membrane potential, cytosolic calcium concentration ([Ca2+]c) and dynamic insulin secretion. In the presence of 10 mmol/l but not of 5 mmol/l glucose, KU14R (30, 100 or 300 micromol/l) was ineffective. KATP channel was blocked by KU14R (IC50 31.9 micromol/l, Hill slope -1.5). KU14R does not act as an antagonist of either efaroxan or S22068 at an imidazoline site in vivo. |
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| Related Catalog | |
| References |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 428.1±34.0 °C at 760 mmHg |
| Melting Point | 137-139ºC |
| Molecular Formula | C13H14N2O |
| Molecular Weight | 214.263 |
| Flash Point | 154.4±15.9 °C |
| Exact Mass | 214.110611 |
| PSA | 37.91000 |
| LogP | 2.10 |
| Vapour Pressure | 0.0±1.0 mmHg at 25°C |
| Index of Refraction | 1.595 |
| Storage condition | Store at RT |